PMID- 20598837 OWN - NLM STAT- MEDLINE DCOM- 20101122 LR - 20240416 IS - 1873-6483 (Electronic) IS - 0740-5472 (Print) IS - 0740-5472 (Linking) VI - 39 IP - 2 DP - 2010 Sep TI - Resets do not appear to increase the rate of adverse events or prolong relapse in voucher-based reinforcement therapy. PG - 167-73 LID - 10.1016/j.jsat.2010.04.002 [doi] AB - Voucher-based reinforcement therapy (VBRT) is an efficacious contingency management intervention for substance use disorders that provides escalating voucher values to reinforce continuous abstinence and typically resets escalated values to the initial low level upon detection of drug use. The objective of this study involving 130 methadone-maintained outpatients receiving VBRT was to investigate whether resets (a) increase risk for adverse events (AEs) and (b) delay return to abstinence in relation to magnitude of voucher reset. Weeks following resets were examined for increased likelihood of AEs using a Poisson regression. A Cox proportional hazards model was used to determine if higher resets increased the number of days until a negative urine specimen. Results showed that resets did not increase the likelihood of AEs nor were higher resets related to an increased delay to abstinence. Research involving larger samples is needed to produce sufficient data directly addressing safety concerns of various treatment stakeholders. CI - Copyright 2010. Published by Elsevier Inc. FAU - Versek, Brian E AU - Versek BE AD - Treatment Research Institute, Philadelphia, PA 19106, USA. bversek@tresearch.org FAU - Carpenedo, Carolyn M AU - Carpenedo CM FAU - Rosenwasser, Beth J AU - Rosenwasser BJ FAU - Dugosh, Karen Leggett AU - Dugosh KL FAU - Bresani, Elena AU - Bresani E FAU - Kirby, Kimberly C AU - Kirby KC LA - eng GR - R01 DA017444/DA/NIDA NIH HHS/United States GR - R01 DA017444-05/DA/NIDA NIH HHS/United States GR - R01 DA 017444/DA/NIDA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20100703 PL - United States TA - J Subst Abuse Treat JT - Journal of substance abuse treatment JID - 8500909 RN - UC6VBE7V1Z (Methadone) SB - IM MH - Adult MH - Cocaine-Related Disorders/psychology/*rehabilitation/urine MH - Female MH - Humans MH - Male MH - Methadone/*therapeutic use MH - Middle Aged MH - Proportional Hazards Models MH - Recurrence MH - Reinforcement Schedule MH - Substance Abuse Detection MH - Time Factors MH - *Token Economy PMC - PMC3072222 MID - NIHMS241189 EDAT- 2010/07/06 06:00 MHDA- 2010/12/14 06:00 PMCR- 2011/09/01 CRDT- 2010/07/06 06:00 PHST- 2009/09/11 00:00 [received] PHST- 2010/03/09 00:00 [revised] PHST- 2010/04/06 00:00 [accepted] PHST- 2010/07/06 06:00 [entrez] PHST- 2010/07/06 06:00 [pubmed] PHST- 2010/12/14 06:00 [medline] PHST- 2011/09/01 00:00 [pmc-release] AID - S0740-5472(10)00094-2 [pii] AID - 10.1016/j.jsat.2010.04.002 [doi] PST - ppublish SO - J Subst Abuse Treat. 2010 Sep;39(2):167-73. doi: 10.1016/j.jsat.2010.04.002. Epub 2010 Jul 3.