PMID- 20599010 OWN - NLM STAT- MEDLINE DCOM- 20100803 LR - 20211020 IS - 1879-1913 (Electronic) IS - 0002-9149 (Print) IS - 0002-9149 (Linking) VI - 106 IP - 2 DP - 2010 Jul 15 TI - Evaluation of papillary muscle function using cardiovascular magnetic resonance imaging in mitral valve prolapse. PG - 243-8 LID - 10.1016/j.amjcard.2010.02.035 [doi] AB - Abnormal traction and excursion of the papillary muscle (PM) can be observed in patients with mitral valve prolapse (MVP) and can adversely affect the electrophysiologic stability of the underlying myocardium. Cardiovascular magnetic resonance (CMR) techniques can directly measure the excursion and velocity of PM tips during ventricular systole. In addition, high-resolution late gadolinium enhancement (LGE) CMR imaging allows for visualization of the underlying potentially arrhythmogenic PM fibrosis substrate. We prospectively studied 16 patients with MVP and 9 healthy adult subjects using phase-contrast CMR and cine CMR to assess the PM velocity and excursion. LGE CMR was performed in 13 patients with MVP (81%). The peak PM systolic velocity and maximum PM excursion were significantly increased in those with MVP (12 +/- 5 vs 5 +/- 2 cm/s and 15 +/- 5 vs 2 +/- 3 mm, both p <0.001). Definite PM LGE was found in 6 patients (46%) but the finding did not correlate with PM velocity or excursion. In conclusion, functional CMR imaging demonstrated increased peak PM systolic velocity and excursion distance in patients with MVP. These parameters, however, did not relate to underlying PM fibrosis. CI - Copyright (c) 2010 Elsevier Inc. All rights reserved. FAU - Han, Yuchi AU - Han Y AD - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. yhan@bidmc.harvard.edu FAU - Peters, Dana C AU - Peters DC FAU - Kissinger, Kraig V AU - Kissinger KV FAU - Goddu, Beth AU - Goddu B FAU - Yeon, Susan B AU - Yeon SB FAU - Manning, Warren J AU - Manning WJ FAU - Nezafat, Reza AU - Nezafat R LA - eng GR - K01 EB004434-01A1/EB/NIBIB NIH HHS/United States GR - K01 EB004434/EB/NIBIB NIH HHS/United States GR - R01 EB008743-01A2/EB/NIBIB NIH HHS/United States GR - R01-EB008743-01A2/EB/NIBIB NIH HHS/United States GR - UL1 RR025758/RR/NCRR NIH HHS/United States GR - R01 EB008743/EB/NIBIB NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 SB - IM MH - Adult MH - Aged MH - Case-Control Studies MH - Female MH - Humans MH - Magnetic Resonance Imaging/methods MH - Male MH - Middle Aged MH - Mitral Valve Prolapse/*diagnosis MH - Papillary Muscles/*physiopathology PMC - PMC2929955 MID - NIHMS217445 EDAT- 2010/07/06 06:00 MHDA- 2010/08/04 06:00 PMCR- 2011/07/15 CRDT- 2010/07/06 06:00 PHST- 2009/12/15 00:00 [received] PHST- 2010/02/24 00:00 [revised] PHST- 2010/02/24 00:00 [accepted] PHST- 2010/07/06 06:00 [entrez] PHST- 2010/07/06 06:00 [pubmed] PHST- 2010/08/04 06:00 [medline] PHST- 2011/07/15 00:00 [pmc-release] AID - S0002-9149(10)00696-X [pii] AID - 10.1016/j.amjcard.2010.02.035 [doi] PST - ppublish SO - Am J Cardiol. 2010 Jul 15;106(2):243-8. doi: 10.1016/j.amjcard.2010.02.035.