PMID- 20599751
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20220321
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 398
IP  - 3
DP  - 2010 Jul 30
TI  - Lectin-like oxidized low-density lipoprotein receptor-1 is required for the 
      adipose tissue expression of proinflammatory cytokines in high-fat diet-induced 
      obese mice.
PG  - 576-80
LID - 10.1016/j.bbrc.2010.06.123 [doi]
AB  - Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a 
      receptor for oxidized LDL, and is strongly expressed in endothelial cells at an 
      early stage of atherosclerosis. LOX-1 expression in adipocytes is induced by 
      PPARgamma (ligands and appears to be involved in adipocyte cholesterol 
      metabolism. However, the role of adipose tissue LOX-1 in high-fat diet-induced 
      obesity is unknown. We found that mRNA levels of adipose tissue LOX-1 were 
      markedly increased in obese mice fed a high-fat diet (HFD) compared with those 
      fed normal chow. The levels were closely correlated with those of a 
      proinflammatory cytokine, monocyte chemoattractant protein-1 (MCP-1). Then, LOX-1 
      knockout (LOX-1-KO) and wild-type (WT) mice were fed HFD for 16weeks. HFD feeding 
      increased the body and mesenteric fat weights similarly in WT and LOX-1-KO mice. 
      HFD-induced expressions of proinflammatory cytokines such as MCP-1, MIP-1alpha, 
      and IL-6 were significantly less in LOX-1-KO than WT mice. Thus, LOX-1 is 
      required for the HFD-induced expression of proinflammatory cytokines in the 
      adipose tissue of obese mice.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Takanabe-Mori, Rieko
AU  - Takanabe-Mori R
AD  - Division of Translational Research, National Hospital Organization Kyoto Medical 
      Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, Japan.
FAU - Ono, Koh
AU  - Ono K
FAU - Sowa, Naoya
AU  - Sowa N
FAU - Wada, Hiromichi
AU  - Wada H
FAU - Takaya, Tomohide
AU  - Takaya T
FAU - Horie, Takahiro
AU  - Horie T
FAU - Satoh-Asahara, Noriko
AU  - Satoh-Asahara N
FAU - Shimatsu, Akira
AU  - Shimatsu A
FAU - Fujita, Masatoshi
AU  - Fujita M
FAU - Sawamura, Tatsuya
AU  - Sawamura T
FAU - Hasegawa, Koji
AU  - Hasegawa K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100701
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Dietary Fats)
RN  - 0 (Scavenger Receptors, Class E)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Chemokine CCL2/biosynthesis
MH  - Cytokines/*biosynthesis
MH  - Diet
MH  - Dietary Fats/*administration & dosage
MH  - Disease Models, Animal
MH  - Mice
MH  - Mice, Knockout
MH  - Obesity/*etiology/genetics/metabolism
MH  - Scavenger Receptors, Class E/genetics/*physiology
EDAT- 2010/07/06 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/06/26 00:00 [received]
PHST- 2010/06/29 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - S0006-291X(10)01263-5 [pii]
AID - 10.1016/j.bbrc.2010.06.123 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2010 Jul 30;398(3):576-80. doi: 
      10.1016/j.bbrc.2010.06.123. Epub 2010 Jul 1.