PMID- 20600442
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20161125
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 10
DP  - 2010 Oct
TI  - Associations between genes for killer immunoglobulin-like receptors and their 
      ligands in patients with solid tumors.
PG  - 976-81
LID - 10.1016/j.humimm.2010.06.019 [doi]
AB  - Killer immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) 
      genotypes were analyzed from panels of lung (non-small-cell lung cancer [NSCLC] 
      and small-cell lung cancer [SCLC]), colon, and kidney cancer patients and 
      compared with normal control subjects. No significant differences were noted 
      between KIR gene frequencies in patients compared with normal subjects. When 
      combinations of KIR genes and their HLA ligands were considered, there were 
      significant decreases in frequencies of both KIR2DL2 and KIR2DL3 in homozygotes 
      for their ligand HLA-C1, and an increase in the frequency of KIR3DL1 and its 
      ligand HLA-Bw4 in kidney cancer patients compared with controls. Both 
      associations were partly attributable to changes in ligand frequencies alone. 
      NSCLC patients showed a significant increase in the frequency of KIR2DL1 and its 
      ligand HLA-C2 and a corresponding decrease in frequency of KIR2DL3 and its ligand 
      HLA-C1 in homozygotes. In NSCLC, the Ile80 form of HLA-Bw4 was decreased in 
      KIR3DL1+ HLA-Bw4+ patients, whereas in SCLC the Ile80 form was increased and the 
      Thr80 form decreased in KIR3DS1+ HLA-Bw4+ patients. These findings are consistent 
      with increased co-expression of high-affinity inhibitory KIRs and their ligands, 
      potentially resulting in decreased natural killer cell function, and hence with 
      natural killer cells having a protective role in lung and kidney cancer but not 
      colon cancer.
CI  - 2010 American Society for Histocompatibility and Immunogenetics. Published by 
      Elsevier Inc. All rights reserved.
FAU - Al Omar, Suliman
AU  - Al Omar S
AD  - Division of Immunology, School of Infection and Host Defence, University of 
      Liverpool, Liverpool, United Kingdom.
FAU - Middleton, Derek
AU  - Middleton D
FAU - Marshall, Ernie
AU  - Marshall E
FAU - Porter, Dawn
AU  - Porter D
FAU - Xinarianos, George
AU  - Xinarianos G
FAU - Raji, Olaide
AU  - Raji O
FAU - Field, John K
AU  - Field JK
FAU - Christmas, Stephen E
AU  - Christmas SE
LA  - eng
PT  - Journal Article
DEP - 20100630
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (Receptors, KIR2DL2)
RN  - 0 (Receptors, KIR2DL3)
SB  - IM
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - HLA-C Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Neoplasms/*genetics/*immunology/pathology/physiopathology
MH  - Receptors, KIR2DL2/*genetics/immunology
MH  - Receptors, KIR2DL3/*genetics/immunology
MH  - United Kingdom
EDAT- 2010/07/06 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2010/06/15 00:00 [revised]
PHST- 2010/06/22 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - S0198-8859(10)00162-X [pii]
AID - 10.1016/j.humimm.2010.06.019 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Oct;71(10):976-81. doi: 10.1016/j.humimm.2010.06.019. Epub 2010 
      Jun 30.