PMID- 20600444
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20111117
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 10
DP  - 2010 Oct
TI  - Human leukocyte antigen-A, -B, and -DRB1 allele and haplotype frequencies in the 
      Mozambican population: a blood donor-based population study.
PG  - 1027-32
LID - 10.1016/j.humimm.2010.06.017 [doi]
AB  - Human leukocyte antigen (HLA) has been used for several decades as genetic 
      markers for analyzing diversity of gene pool origin, platelet transfusion, tissue 
      transplantation, disease susceptibility or resistance, and forensic and 
      anthropological studies. In the present study, the allele and haplotype 
      frequencies of HLA-A, -B, and -DRB1 were studied in 250 unrelated Mozambican 
      individuals (black African from south of Mozambique Basin) by using a low-medium 
      resolution polymerase chain reaction-Luminex typing method. A total of 18 A, 25 
      B, and 13 DRB1 alleles were identified. The most frequent HLA-A, -B, and -DRB1 
      alleles were HLA-A*30 (23.9%), HLA-B*15 (15.6%), and HLA-DRB1*13 (19.8%), 
      respectively. The most frequent two-locus haplotypes were HLA-A*30-B*42 (7.4%) 
      and HLA-B*42-DRB1*03 (5.4%), and three-locus haplotypes were 
      HLA-A*30-B*42-DRB1*03 (4.9%), and HLA-A*02-B*58-DRB1*11 (4.1%). Allele 
      distribution and haplotype analysis demonstrated that Mozambican population 
      shares HLA patterns with sub-Saharan populations.
CI  - 2010 American Society for Histocompatibility and Immunogenetics. Published by 
      Elsevier Inc. All rights reserved.
FAU - Assane, Antonio A A
AU  - Assane AA
AD  - Histocompatibility and Cryopreservation Laboratory, Department of Histology and 
      Embryology, Roberto Alcantara Gomes Institute of Biology, Rio de Janeiro State 
      University, Rio de Janeiro, RJ, Brazil.
FAU - Fabricio-Silva, Gustavo M
AU  - Fabricio-Silva GM
FAU - Cardoso-Oliveira, Juliana
AU  - Cardoso-Oliveira J
FAU - Mabunda, Nedio E J
AU  - Mabunda NE
FAU - Sousa, Amina M
AU  - Sousa AM
FAU - Jani, Ilesh V
AU  - Jani IV
FAU - Ferreira, Orlando C Jr
AU  - Ferreira OC Jr
FAU - Porto, Luis C M S
AU  - Porto LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100630
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Donors
MH  - Female
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mozambique
MH  - Population
EDAT- 2010/07/06 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/02/27 00:00 [received]
PHST- 2010/06/15 00:00 [revised]
PHST- 2010/06/22 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - S0198-8859(10)00160-6 [pii]
AID - 10.1016/j.humimm.2010.06.017 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Oct;71(10):1027-32. doi: 10.1016/j.humimm.2010.06.017. Epub 
      2010 Jun 30.