PMID- 20600447
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20100827
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 9
DP  - 2010 Sep
TI  - Tumor necrosis factor-alpha polymorphisms and expression in Guillain-Barre 
      syndrome.
PG  - 905-10
LID - 10.1016/j.humimm.2010.06.013 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) polymorphisms with increased expression 
      is associated with many autoimmune and inflammatory diseases. Possible role of 
      TNF-alpha polymorphism in the pathogenesis of Guillain-Barre syndrome (GBS) 
      largely remains unknown. We investigated polymorphisms in the promoter region of 
      TNF-alpha gene and its expression in GBS patients and healthy controls. TNF-alpha 
      (-308 G>A, -857 C>T, and -863 C>A) polymorphisms in 140 GBS patients and 206 
      healthy controls were studied using polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP) and allele specific-PCR. TNF-alpha level 
      in serum by ELISA was determined in 60 patients and an equal number of controls. 
      Prevalence of TNF-alpha -308 G > A polymorphic A allele was associated with 
      increased risk of GBS (p < 0.001; OR = 2.58, 95% CI = 1.61-4.14). Heterozygous 
      genotype (G/A) had an association with acute motor axonal neuropathy (p < 0.001; 
      OR = 4.23, 95% CI = 2.00-8.95) and variant genotype A/A with both axonal 
      subtypes, acute motor axonal neuropathy (p = 0.015, OR = 7.00, 95% CI = 
      1.46-33.57) and acute motor sensory axonal neuropathy (p = 0.017; OR = 7.73, 95% 
      CI = 1.44-41.37). Variant genotype T/T of TNF-alpha -857 C>T polymorphism was 
      also significantly associated with acute motor axonal neuropathy (p = 0.034; OR = 
      3.93, 95% CI = 1.11-13.91). Patients with A and T alleles had higher TNF-alpha 
      level in serum. TNF-alpha -308 G > A and -857 C>T (only T/T) polymorphisms with 
      increased TNF-alpha level may predict susceptibility to axonal subtypes of GBS.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Prasad, Kashi N
AU  - Prasad KN
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, Uttar Pradesh, India. knprasad@sgpgi.ac.in
FAU - Nyati, Kishan K
AU  - Nyati KK
FAU - Verma, Avantika
AU  - Verma A
FAU - Rizwan, Arshi
AU  - Rizwan A
FAU - Paliwal, Vimal K
AU  - Paliwal VK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100619
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Guillain-Barre Syndrome/blood/classification/diagnosis/*genetics
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/blood/*genetics
EDAT- 2010/07/06 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/03/26 00:00 [received]
PHST- 2010/06/09 00:00 [revised]
PHST- 2010/06/11 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0198-8859(10)00156-4 [pii]
AID - 10.1016/j.humimm.2010.06.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Sep;71(9):905-10. doi: 10.1016/j.humimm.2010.06.013. Epub 2010 
      Jun 19.