PMID- 20600449
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20100827
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 9
DP  - 2010 Sep
TI  - Origins and relatedness of human leukocyte antigen class I allele supertypes.
PG  - 837-42
LID - 10.1016/j.humimm.2010.06.010 [doi]
AB  - Class I human leukocyte antigen (HLA) alleles can be classified into supertypes 
      based on the epitope specificity of their peptide binding grooves. The 
      evolutionary origin of these supertypes has been the topic of prior research and 
      remains an important question because of the increasing interest in HLA 
      supertypes in the contexts of infection and cancer epidemiology and vaccine 
      development. Here I re-examine the origins of HLA class I supertypes using the 
      nucleotide sequences of 88 HLA-A alleles and 117 HLA-B alleles. Phylogenetic 
      trees with ancestral character state reconstruction show that the HLA-A02, A03, 
      and A24 supertypes largely form clades with a single ancestral origin while 
      HLA-A01 shows multiple independent origins all from HLA-A03 ancestors. HLA-B 
      supertypes show multiple origins for the B07, B08, and B27 supertypes, while the 
      B44, B58, and B62 supertypes largely form clades with a single ancestor. 
      Supertypes arising multiple times show different amino acid substitutions in each 
      clade. These findings suggest that convergent evolution has occurred in only a 
      few HLA allele supertypes and may indicate different evolutionary pressures 
      shaping certain supertypes.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Naugler, Christopher
AU  - Naugler C
AD  - Department of Pathology and Laboratory Medicine, Dalhousie University, Halifax, 
      Nova Scotia, Canada. Christopher.Naugler@CLS.ab.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100619
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - *Alleles
MH  - Amino Acid Substitution/genetics/immunology
MH  - Base Sequence/genetics
MH  - Binding Sites/genetics/immunology
MH  - Databases, Nucleic Acid
MH  - *Evolution, Molecular
MH  - Exons/genetics
MH  - Genes, MHC Class I/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - Humans
MH  - *Phylogeny
MH  - Selection, Genetic/genetics/immunology
MH  - Sequence Alignment
EDAT- 2010/07/06 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/07/06 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2010/05/21 00:00 [revised]
PHST- 2010/06/07 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0198-8859(10)00153-9 [pii]
AID - 10.1016/j.humimm.2010.06.010 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Sep;71(9):837-42. doi: 10.1016/j.humimm.2010.06.010. Epub 2010 
      Jun 19.