PMID- 20600450
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20211020
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 9
DP  - 2010 Sep
TI  - Transcript abundance patterns in Kawasaki disease patients with intravenous 
      immunoglobulin resistance.
PG  - 865-73
LID - 10.1016/j.humimm.2010.06.008 [doi]
AB  - Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients 
      comprise at least 20% of treated patients and are at high risk for coronary 
      artery abnormalities. If identified early in the course of the disease, such 
      patients may benefit from additional anti-inflammatory therapy. The aim of this 
      study was to compare the transcript abundance between IVIG resistant and 
      -responsive KD patients, to identify biomarkers that might differentiate between 
      these two groups and to generate new targets for therapies in IVIG resistant KD 
      patients. We compared the transcript abundance profiles of whole-blood RNA on 
      Agilent arrays from acute and convalescent KD subjects and age-similar, healthy 
      controls. KD subjects were stratified as IVIG resistant or -responsive based on 
      response to initial IVIG therapy. Transcript abundance was higher for IL-1 
      pathway genes (IL-1 receptor, interleukin receptor associated kinase, p38 
      mitogen-activated protein kinase), and MMP-8. These findings point to candidate 
      biomarkers that may predict IVIG resistance in acute KD patients. The results 
      also underscore the importance of the IL-1 pathway as a mediator of inflammation 
      in KD and suggest that IL-1 or its receptor may be reasonable targets for 
      therapy, particularly for IVIG resistant patients.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Fury, Wen
AU  - Fury W
AD  - Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
FAU - Tremoulet, Adriana H
AU  - Tremoulet AH
FAU - Watson, Virginia E
AU  - Watson VE
FAU - Best, Brookie M
AU  - Best BM
FAU - Shimizu, Chisato
AU  - Shimizu C
FAU - Hamilton, Jennifer
AU  - Hamilton J
FAU - Kanegaye, John T
AU  - Kanegaye JT
FAU - Wei, Yi
AU  - Wei Y
FAU - Kao, Chiayi
AU  - Kao C
FAU - Mellis, Scott
AU  - Mellis S
FAU - Lin, Calvin
AU  - Lin C
FAU - Burns, Jane C
AU  - Burns JC
LA  - eng
GR  - HL69413/HL/NHLBI NIH HHS/United States
GR  - R01 HL069413-08/HL/NHLBI NIH HHS/United States
GR  - R01 HL069413/HL/NHLBI NIH HHS/United States
GR  - K24 HL074864/HL/NHLBI NIH HHS/United States
GR  - K24 HL074864-05/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100620
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers)
RN  - 0 (CD66 antigens)
RN  - 0 (CEACAM8 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (IL1R2 protein, human)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Interleukin-1)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interleukin-1 Type II)
RN  - 0 (S100 Proteins)
RN  - 80295-33-6 (Complement C1q)
RN  - EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
SB  - IM
MH  - Antigens, CD/genetics
MH  - Biomarkers/blood
MH  - Cell Adhesion Molecules/genetics
MH  - Child
MH  - Child, Preschool
MH  - Complement C1q/genetics
MH  - Drug Resistance/*genetics
MH  - Female
MH  - GPI-Linked Proteins/genetics
MH  - Gene Expression/genetics
MH  - *Gene Expression Profiling
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Infant
MH  - Interleukin-1/metabolism
MH  - Interleukin-1 Receptor-Associated Kinases/genetics
MH  - Male
MH  - Matrix Metalloproteinase 8/blood/genetics
MH  - Mucocutaneous Lymph Node Syndrome/blood/*drug therapy/*genetics
MH  - NF-kappa B/genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - RNA, Messenger/*analysis/genetics
MH  - Receptors, Interleukin-1 Type II/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - S100 Proteins/genetics
MH  - Signal Transduction/genetics
MH  - Transcription, Genetic/*genetics
MH  - Up-Regulation/genetics
PMC - PMC2929310
MID - NIHMS217383
EDAT- 2010/07/06 06:00
MHDA- 2011/02/01 06:00
PMCR- 2011/09/01
CRDT- 2010/07/06 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2010/05/30 00:00 [revised]
PHST- 2010/06/04 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - S0198-8859(10)00151-5 [pii]
AID - 10.1016/j.humimm.2010.06.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Sep;71(9):865-73. doi: 10.1016/j.humimm.2010.06.008. Epub 2010 
      Jun 20.