PMID- 20600612
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20150528
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 480
IP  - 3
DP  - 2010 Aug 23
TI  - Pinoresinol from the fruits of Forsythia koreana inhibits inflammatory responses 
      in LPS-activated microglia.
PG  - 215-20
LID - 10.1016/j.neulet.2010.06.043 [doi]
AB  - The activation of microglia plays an important role in a variety of brain 
      disorders by the excessive production of inflammatory mediators such as nitric 
      oxide (NO), prostaglandin E(2) (PGE(2)) and proinflammatory cytokines. We 
      investigated here whether pinoresinol isolated from the fruits of Forsythia 
      koreana Nakai inhibits the inflammatory responses in LPS-activated microglia. 
      Pinoresinol inhibited the production of NO, PGE(2), TNF-alpha, IL-1beta and IL-6 
      in LPS-activated primary microglia. Also, pinoresinol attenuated mRNA and protein 
      levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and 
      proinflammatory cytokines in LPS-activation. However, most of these inhibitory 
      effects of pinoresinol have been mediated by extracellular-signal-regulated 
      kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) phosphorylation and the 
      NF-kappaB dependent. The results suggest that pinoresinol attenuates inflammatory 
      responses of microglia and could be potentially useful in modulation of 
      inflammatory status in brain disorders.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Jung, Hyo Won
AU  - Jung HW
AD  - Oriental Medicine R&D Center, Dongguk University, Gyeongju 780-714, South Korea.
FAU - Mahesh, Ramalingam
AU  - Mahesh R
FAU - Lee, Jong Gu
AU  - Lee JG
FAU - Lee, Seung Ho
AU  - Lee SH
FAU - Kim, Young Shik
AU  - Kim YS
FAU - Park, Yong-Ki
AU  - Park YK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100619
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cytokines)
RN  - 0 (Furans)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Lignans)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - V4N1UDY811 (pinoresinol)
SB  - IM
EIN - Neurosci Lett. 2015 Jan 12;585:66
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology/therapeutic use
MH  - Cells, Cultured
MH  - Cytokines/antagonists & inhibitors
MH  - Dinoprostone/antagonists & inhibitors
MH  - *Forsythia
MH  - Furans/*pharmacology/therapeutic use
MH  - Gliosis/chemically induced/*drug therapy/physiopathology
MH  - Inflammation Mediators/antagonists & inhibitors/pharmacology
MH  - Lignans/*pharmacology/therapeutic use
MH  - Lipopolysaccharides/antagonists & inhibitors/pharmacology
MH  - Microglia/*drug effects/metabolism
MH  - Nitric Oxide/antagonists & inhibitors
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/07/06 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/06/11 00:00 [revised]
PHST- 2010/06/14 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - S0304-3940(10)00791-3 [pii]
AID - 10.1016/j.neulet.2010.06.043 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Aug 23;480(3):215-20. doi: 10.1016/j.neulet.2010.06.043. Epub 
      2010 Jun 19.