PMID- 20601026
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20131121
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 94
IP  - 2
DP  - 2010 Sep
TI  - Molecular mechanisms in hippocampus and basolateral amygdala but not in parietal 
      or cingulate cortex are involved in extinction of one-trial avoidance learning.
PG  - 285-91
LID - 10.1016/j.nlm.2010.06.007 [doi]
AB  - The establishment of extinction of one-trial avoidance involves the dorsal 
      hippocampus (DH) and basolateral amygdala (BLA), two areas that participate in 
      its original consolidation. The posterior parietal (PARIE) and posterior 
      cingulate (CING) cortices also participate in consolidation of this task but 
      their role in extinction has not been explored. Here we study the effect on the 
      extinction of one-trial avoidance in rats of three different drugs infused 
      bilaterally into DH, BLA, PARIE or CING 5min before the first of four daily 
      unreinforced test sessions: The glutamate NMDA receptor antagonist, AP5 
      (5.0microg/side),and the inhibitors of calcium-calmodulin dependent kinase II 
      (CaMKII), KN-93 (0.3microg/side), or of the cAMP-dependent protein kinase (PKA), 
      Rp-cAMPs (0.5microg/side) hindered extinction when given into DH or BLA. Levels 
      of pPKA and pCaMKII increased in DH after the first extinction trial; in BLA only 
      the CaMKII increase was seen. Thus, this pathway appears to participate in 
      extinction in BLA at the "basal" levels, and at enhanced levels in DH. None of 
      the treatments affected extinction when given into PARIE or CING. The present 
      findings indicate that: (1) the DH and BLA are important for the initiation of 
      extinction at the time of the first unreinforced retrieval session; (2) both the 
      CaMKII and the PKA signaling pathway are necessary for the development of 
      extinction in the two regions; (3) PARIE and CING are probably unrelated to 
      extinction.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Myskiw, Jociane C
AU  - Myskiw JC
AD  - Centro de Memoria, Instituto do Cerebro, Pontifical Catholic University of Rio 
      Grande do Sul, Av. Ipiranga 6690, 2nd floor, 90610-000 Porto Alegre, RS, Brazil.
FAU - Fiorenza, Natalia G
AU  - Fiorenza NG
FAU - Izquierdo, Luciana A
AU  - Izquierdo LA
FAU - Izquierdo, Ivan
AU  - Izquierdo I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100630
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Benzylamines)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Sulfonamides)
RN  - 0 (Thionucleotides)
RN  - 139298-40-1 (KN 93)
RN  - 23645-17-2 (adenosine-3',5'-cyclic phosphorothioate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Amygdala/drug effects/*enzymology
MH  - Animals
MH  - Avoidance Learning/*physiology
MH  - Benzylamines/pharmacology
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/drug effects/*metabolism
MH  - Cyclic AMP/analogs & derivatives/pharmacology
MH  - Cyclic AMP-Dependent Protein Kinases/drug effects/*metabolism
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Extinction, Psychological/drug effects/*physiology
MH  - Gyrus Cinguli/drug effects/enzymology
MH  - Hippocampus/drug effects/*enzymology
MH  - Male
MH  - Microinjections
MH  - Parietal Lobe/drug effects/enzymology
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
MH  - Second Messenger Systems/drug effects/physiology
MH  - Signal Transduction/drug effects/physiology
MH  - Sulfonamides/pharmacology
MH  - Thionucleotides/pharmacology
EDAT- 2010/07/06 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/04/06 00:00 [received]
PHST- 2010/06/05 00:00 [revised]
PHST- 2010/06/25 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1074-7427(10)00110-3 [pii]
AID - 10.1016/j.nlm.2010.06.007 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2010 Sep;94(2):285-91. doi: 10.1016/j.nlm.2010.06.007. Epub 
      2010 Jun 30.