PMID- 20602183
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20211020
IS  - 1534-6269 (Electronic)
IS  - 1523-3790 (Print)
IS  - 1523-3790 (Linking)
VI  - 12
IP  - 5
DP  - 2010 Sep
TI  - Haploidentical transplantation for leukemia.
PG  - 292-301
LID - 10.1007/s11912-010-0113-4 [doi]
AB  - Hematopoietic stem cell transplantation from human leukocyte antigen 
      (HLA)-haploidentical family members offers a potential cure for patients in need 
      of allogeneic immunotherapy who have no immediate access to an HLA-matched donor. 
      The use of ex vivo T-cell-depleted stem cells combined with immuno-myeloablative 
      conditioning has enabled durable donor engraftment with a low incidence of acute 
      graft-versus-host disease despite the HLA disparity. Moreover, additional 
      transplant techniques involving in vivo T-cell depletion and reduced-intensity 
      conditioning have further minimized the risks. However, a major drawback is 
      delayed immune reconstitution leading to infections and high relapse rates, 
      prompting significant research efforts focused on improving recovery in the 
      post-transplant period. Infusions with donor lymphocytes are common, though newer 
      manipulations with a focus on donor natural killer cells hold great promise, as 
      do other modified donor T-cell infusions. Success of these new procedures will 
      make haploidentical transplants safer and more effective, further broadening its 
      appeal.
FAU - Kanda, Junya
AU  - Kanda J
AD  - Division of Cellular Therapy, Department of Medicine, Duke University Medical 
      Center, Durham, NC 27705, USA.
FAU - Chao, Nelson J
AU  - Chao NJ
FAU - Rizzieri, David A
AU  - Rizzieri DA
LA  - eng
GR  - P01 CA047741/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Oncol Rep
JT  - Current oncology reports
JID - 100888967
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Clinical Trials as Topic
MH  - *Graft Survival
MH  - HLA Antigens/metabolism
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility
MH  - Humans
MH  - Leukemia/*therapy
MH  - Transplantation, Homologous
PMC - PMC3874937
MID - NIHMS519682
EDAT- 2010/07/06 06:00
MHDA- 2010/11/06 06:00
PMCR- 2013/12/30
CRDT- 2010/07/06 06:00
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
PHST- 2013/12/30 00:00 [pmc-release]
AID - 10.1007/s11912-010-0113-4 [doi]
PST - ppublish
SO  - Curr Oncol Rep. 2010 Sep;12(5):292-301. doi: 10.1007/s11912-010-0113-4.