PMID- 20602942
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20131121
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 82
IP  - 2
DP  - 2010 Jul 15
TI  - The role of the acquisition methods in the analysis of the non-steroidal 
      anti-inflammatory drugs in Danube River by gas chromatography-mass spectrometry.
PG  - 600-7
LID - 10.1016/j.talanta.2010.05.014 [doi]
AB  - In this paper authors describe a GC-MS acquisition study, relating to the most 
      common, non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, 
      naproxen, ketoprofen and diclofenac. As novelties to the field, for the 
      trimethylsilyl (TMS) oxime ester derivatives of NSAIDs, at first, a tandem mass 
      spectrometric (MS/MS) acquisition method has been developed, and, also for the 
      first time, the three acquisition techniques, the full scan (FS), the selective 
      ion monitoring (SIM) and the currently optimized MS/MS ones, have been compared: 
      all three in parallel, under strictly the same derivatization/instrumental 
      conditions, both from model solutions and from the Danube River samples. Critical 
      evaluation of the three acquisition protocols was collated on their analytical 
      performances and validated with the same characteristics like the six point 
      calibration curve, the relative standard deviation percentages (RSD%) of parallel 
      tests, the limit of quantitation (LOQ) and the instrumental limit of quantitation 
      (ILQ) values. Data of six point calibration (r(2)>or=0.997) and RSD% (average: 
      5.8 RSD%) values proved to be independent on the acquisition methods, while, LOQ 
      and ILQ values furnished considerable differences. Decreasing LOQ data, 
      (expressed in ng/L concentrations) were obtained in the FS, SIM, MS/MS line for 
      ibuprofen (1.0, 0.43, 0.41), naproxen (1.1, 1.0, 0.42), ketoprofen (2.6, 1.0, 
      0.49) and diclofenac (1.4, 0.41, 0.21), respectively. The same trend was 
      determined in terms of the ILQ values. The practical utility of the optimized 
      MS/MS technique was confirmed by the quantitation of the NSAID contents of the 
      Danube River samples, determined by all three acquisition techniques. Results 
      obtained confirmed the primary importance of the MS/MS acquisition method, even 
      in comparison to the SIM one: avoiding the extreme overestimation of the 
      ibuprofen (approximately 100%) and ketoprofen (approximately 400%) concentrations 
      in the Danube River samples.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Helenkar, A
AU  - Helenkar A
AD  - Institute of Chemistry Department of Analytical Chemistry, L. Eotvos University, 
      Budapest, Hungary.
FAU - Sebok, A
AU  - Sebok A
FAU - Zaray, Gy
AU  - Zaray G
FAU - Molnar-Perl, I
AU  - Molnar-Perl I
FAU - Vasanits-Zsigrai, A
AU  - Vasanits-Zsigrai A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100611
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Water Pollutants, Chemical)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 57Y76R9ATQ (Naproxen)
RN  - 90Y4QC304K (Ketoprofen)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*analysis/chemistry
MH  - Diclofenac/analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Ibuprofen/analysis
MH  - Ketoprofen/analysis
MH  - Limit of Detection
MH  - Naproxen/analysis
MH  - Rivers/*chemistry
MH  - Water Pollutants, Chemical/analysis
EDAT- 2010/07/07 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/04/28 00:00 [revised]
PHST- 2010/05/10 00:00 [accepted]
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S0039-9140(10)00354-1 [pii]
AID - 10.1016/j.talanta.2010.05.014 [doi]
PST - ppublish
SO  - Talanta. 2010 Jul 15;82(2):600-7. doi: 10.1016/j.talanta.2010.05.014. Epub 2010 
      Jun 11.