PMID- 20603315
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20220409
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 207
IP  - 7
DP  - 2010 Jul 5
TI  - PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors.
PG  - 1347-50
LID - 10.1084/jem.20101156 [doi]
AB  - Expression of the regulatory T (T reg) cell-associated transcription factor Foxp3 
      can be induced by signals from the T cell receptor (TCR), interleukin-2 (IL-2), 
      and transforming growth factor (TGF)-beta. These signals are integrated by a 
      network involving phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB; 
      here referred to as Akt), and the mammalian target of rapamycin (mTOR). New 
      studies show that the Foxo proteins Foxo1 and Foxo3a, which are inactivated by 
      Akt, drive Foxp3 expression. These studies therefore explain the negative 
      regulation of Foxp3 by PI3K signaling, and add Foxo proteins to the growing list 
      of nuclear factors capable of modulating Foxp3 expression.
FAU - Merkenschlager, Matthias
AU  - Merkenschlager M
AD  - Lymphocyte Development Group, Medical Research Council Clinical Sciences Centre, 
      Imperial College London, London W12 0NN, UK. 
      matthias.merkenschlager@csc.mrc.ac.uk
FAU - von Boehmer, Harald
AU  - von Boehmer H
LA  - eng
GR  - MC_U120027516/MRC_/Medical Research Council/United Kingdom
GR  - R37 AI053102/AI/NIAID NIH HHS/United States
GR  - R37 AI 53102/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
CIN - Harada et al.
MH  - Animals
MH  - Conserved Sequence
MH  - Forkhead Transcription Factors/*metabolism
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Models, Biological
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases
PMC - PMC2901062
EDAT- 2010/07/07 06:00
MHDA- 2010/07/31 06:00
PMCR- 2011/01/05
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
PHST- 2011/01/05 00:00 [pmc-release]
AID - 20101156 [pii]
AID - 10.1084/jem.20101156 [doi]
PST - ppublish
SO  - J Exp Med. 2010 Jul 5;207(7):1347-50. doi: 10.1084/jem.20101156.