PMID- 20604895
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 5
DP  - 2010 Nov
TI  - Estimating unbiased haplotype frequencies from stem cell donor samples typed at 
      heterogeneous resolutions: a practical study based on over 1 million German 
      donors.
PG  - 352-61
LID - 10.1111/j.1399-0039.2010.01518.x [doi]
AB  - The human leukocyte antigen (HLA) distribution in donor registry data is 
      typically nonrandom as, mostly for economical reasons, typing additional loci or 
      resolving ambiguities is selectively performed based on the previously known HLA 
      type. Analyzing a sample of over 1 million German stem cell donors, we 
      practically show the extent of the bias caused by the restriction of the input 
      data for HLA haplotype frequency (HF) estimation to subsets selected according to 
      their higher HLA typing resolution and, conversely, the correctness of estimates 
      based on unselected data with a methodology suitable for heterogeneous 
      resolution. We discuss algorithmic aspects of this approach and, also because of 
      the sample size, provide some new insights into the distribution of HLA-DRB1 
      alleles in the German population and the application of HFs in unrelated donor 
      search.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Eberhard, H-P
AU  - Eberhard HP
AD  - ZKRD - Zentrales Knochenmarkspender-Register fur Deutschland, German National 
      Bone Marrow Donor Registry, Ulm, Germany.
FAU - Feldmann, U
AU  - Feldmann U
FAU - Bochtler, W
AU  - Bochtler W
FAU - Baier, D
AU  - Baier D
FAU - Rutt, C
AU  - Rutt C
FAU - Schmidt, A H
AU  - Schmidt AH
FAU - Muller, C R
AU  - Muller CR
LA  - eng
PT  - Journal Article
DEP - 20100819
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Algorithms
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - Germany
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Male
MH  - Registries/statistics & numerical data
MH  - *Tissue Donors
EDAT- 2010/07/08 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - TAN1518 [pii]
AID - 10.1111/j.1399-0039.2010.01518.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Nov;76(5):352-61. doi: 10.1111/j.1399-0039.2010.01518.x. 
      Epub 2010 Aug 19.