PMID- 20604978
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20211028
IS  - 1741-0533 (Electronic)
IS  - 1740-925X (Linking)
VI  - 6
IP  - 1
DP  - 2010 Feb
TI  - Expression and contribution of satellite glial cells purinoceptors to pain 
      transmission in sensory ganglia: an update.
PG  - 31-42
LID - 10.1017/S1740925X10000086 [doi]
AB  - The role of adenosine-5'-triphosphate (ATP) and of the ligand-gated P2X3 receptor 
      in neuronal dorsal root ganglia (DRG) pain transmission is relatively well 
      established. Much less is known about the purinergic system in trigeminal ganglia 
      (TG), which are involved in certain types of untreatable neuropathic and 
      inflammatory pain, as well as in migraine. Emerging data suggest that purinergic 
      metabotropic P2Y receptors on both neurons and satellite glial cells (SGCs) may 
      also participate in both physiological and pathological pain development. Here, 
      we provide an updated literature review on the role of purinergic signaling in 
      sensory ganglia, with special emphasis on P2Y receptors on SGCs. We also provide 
      new original data showing a time-dependent downregulation of P2Y2 and P2Y4 
      receptor expression and function in purified SGCs cultures from TG, in comparison 
      with primary mixed neuron-SGCs cultures. These data highlight the importance of 
      the neuron-glia cross-talk in determining the SGCs phenotype. Finally, we show 
      that, in mixed TG cultures, both adenine and guanosine induce intracellular 
      calcium transients in neurons but not in SGCs, suggesting that also these 
      purinergic-related molecules can participate in pain signaling. These findings 
      may have relevant implications for the development of new therapeutic strategies 
      for chronic pain treatment.
FAU - Villa, Giovanni
AU  - Villa G
AD  - Laboratory of Molecular and Cellular, Pharmacology of Purinergic Transmission, 
      Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, 
      Italy.
FAU - Fumagalli, Marta
AU  - Fumagalli M
FAU - Verderio, Claudia
AU  - Verderio C
FAU - Abbracchio, Maria P
AU  - Abbracchio MP
FAU - Ceruti, Stefania
AU  - Ceruti S
LA  - eng
GR  - GGP07032/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuron Glia Biol
JT  - Neuron glia biology
JID - 101217278
RN  - 0 (Receptors, Purinergic)
RN  - 12133JR80S (Guanosine)
RN  - 61D2G4IYVH (Adenosine Diphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - SY7Q814VUP (Calcium)
RN  - UT0S826Z60 (Uridine Triphosphate)
SB  - IM
MH  - Adenosine Diphosphate/pharmacology
MH  - Adenosine Triphosphate/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Calcium/metabolism
MH  - Coculture Techniques/methods
MH  - Ganglia, Spinal/*cytology
MH  - Gene Expression Regulation/drug effects
MH  - Guanosine/pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuroglia/drug effects/*physiology
MH  - Neurons/drug effects/physiology
MH  - Receptors, Purinergic/*classification/genetics/*metabolism
MH  - Time Factors
MH  - Trigeminal Ganglion/*cytology
MH  - Uridine Triphosphate/pharmacology
EDAT- 2010/07/08 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - S1740925X10000086 [pii]
AID - 10.1017/S1740925X10000086 [doi]
PST - ppublish
SO  - Neuron Glia Biol. 2010 Feb;6(1):31-42. doi: 10.1017/S1740925X10000086.