PMID- 20605247
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20220310
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 90
IP  - 1
DP  - 2010 Oct
TI  - Correlation between glucose fluctuations and carotid intima-media thickness in 
      type 2 diabetes.
PG  - 95-9
LID - 10.1016/j.diabres.2010.05.004 [doi]
AB  - AIMS: To evaluate the relationship between blood glucose fluctuations and carotid 
      atherosclerosis (AS) in type 2 diabetic patients. METHODS: A case-control study 
      included 36 patients with type 2 diabetes and 10 controls. According to the 
      levels of carotid intima-media thickness (CIMT), 36 diabetic patients were 
      classified into two groups, the diabetes mellitus without atherosclerosis (DM-AS, 
      n=20) and diabetes mellitus with atherosclerosis (DM+AS, n=16). The glucose 
      excursions were assessed by the following parameters obtained from continuous 
      glucose monitoring system for 72h: the mean blood glucose (MBG) and its standard 
      deviation (SD), the area under the ROC curve when the blood glucose was higher 
      than 7.8mmol/L (AUC7.8), the mean amplitude of glycemic excursion (MAGE), the 
      mean of daily differences (MODD), and the largest amplitude of glycemic excursion 
      (LAGE). RESULTS: The levels of MBG, SD, MAGE, LAGE, and AUC7.8 were gradually 
      increased with the progression of atherosclerosis (P<0.05). The Spearman's 
      correlation analysis showed that the CIMT was correlated to the age (R=0.58, 
      P<0.001), the duration (R=0.50, P<0.001), the MAGE (R=0.34, P=0.021), and the 
      LAGE (R=0.31, P=0.035). CONCLUSION: These results suggest that glucose 
      fluctuations may accelerate atherogenesis in older type 2 diabetic patients who 
      had a longer duration.
FAU - Chen, Xiao-min
AU  - Chen XM
AD  - Department of Endocrinology and Metabolism, Zhongshan Hospital Affiliated to 
      Xiamen University, Xiamen, PR China. chenxiaomin0517@sina.com
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Shen, Xing-ping
AU  - Shen XP
FAU - Huang, Qun
AU  - Huang Q
FAU - Ma, Hong
AU  - Ma H
FAU - Huang, Yang-Ling
AU  - Huang YL
FAU - Zhang, Wen-Qiang
AU  - Zhang WQ
FAU - Wu, Hao-Jie
AU  - Wu HJ
LA  - eng
PT  - Journal Article
DEP - 20100603
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging
MH  - Atherosclerosis/diagnostic imaging/epidemiology/pathology
MH  - Blood Glucose/*analysis
MH  - Carotid Arteries/diagnostic imaging/*pathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/*complications/pathology
MH  - Diabetic Angiopathies/blood/diagnostic imaging/*epidemiology/pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Ambulatory
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Tunica Intima/diagnostic imaging/*pathology
MH  - Tunica Media/diagnostic imaging/*pathology
MH  - Ultrasonography
EDAT- 2010/07/08 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/05/01 00:00 [revised]
PHST- 2010/05/06 00:00 [accepted]
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - S0168-8227(10)00234-2 [pii]
AID - 10.1016/j.diabres.2010.05.004 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2010 Oct;90(1):95-9. doi: 10.1016/j.diabres.2010.05.004. 
      Epub 2010 Jun 3.