PMID- 20605908
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20211020
IS  - 1521-0103 (Electronic)
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 335
IP  - 1
DP  - 2010 Oct
TI  - Dopamine uptake inhibitors but not dopamine releasers induce greater increases in 
      motor behavior and extracellular dopamine in adolescent rats than in adult male 
      rats.
PG  - 124-32
LID - 10.1124/jpet.110.167320 [doi]
AB  - Most life-long drug addiction begins during adolescence. Important structural and 
      functional changes in brain occur during adolescence and developmental 
      differences in forebrain dopamine systems could mediate a biologic vulnerability 
      to drug addiction during adolescence. Studies investigating age differences in 
      psychostimulant responses have yielded mixed results, possibly because of 
      different mechanisms for increasing extracellular dopamine. Recent research from 
      our laboratory suggests that adolescent dopamine systems may be most affected by 
      selective dopamine uptake inhibitors. We investigated age-related behavioral 
      responses to acute administration of several dopamine uptake inhibitors 
      [methylphenidate, 
      1-2-[bis-(4-fluorophenyl)methoxy]ethyl-4-(3-phenylpropyl)piperazine (GBR12909), 
      and nomifensine] and releasing agents [amphetamine and 
      methylenedioxymethamphetamine (MDMA)] in adolescent and adult male rats. 
      Methylphenidate and amphetamine effects on stimulated dopamine efflux were 
      determined using fast-scan cyclic voltammetry in vivo. Dopamine uptake inhibitors 
      but not dopamine releasing agents induced more locomotion and/or stereotypy in 
      adolescent relative to adult rats. MDMA effects were greater in adults at early 
      time points after dosing. Methylphenidate but not amphetamine induced much 
      greater dopamine efflux in periadolescent relative to adult rats. Periadolescent 
      male rats are particularly sensitive to psychostimulants that are DAT inhibitors 
      but are not internalized and do not release dopamine. Immaturity of DAT and/or 
      DAT associated signaling systems in adolescence specifically enhances behavioral 
      and dopaminergic responses in adolescence.
FAU - Walker, Q David
AU  - Walker QD
AD  - Department of Pharmacology and Cancer Biology, Duke University Medical Center, 
      Durham, NC 27710, USA.
FAU - Morris, Sarah E
AU  - Morris SE
FAU - Arrant, Andrew E
AU  - Arrant AE
FAU - Nagel, Jacqueline M
AU  - Nagel JM
FAU - Parylak, Sarah
AU  - Parylak S
FAU - Zhou, Guiying
AU  - Zhou G
FAU - Caster, Joseph M
AU  - Caster JM
FAU - Kuhn, Cynthia M
AU  - Kuhn CM
LA  - eng
GR  - R01 DA019114/DA/NIDA NIH HHS/United States
GR  - DA019114/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100706
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Amphetamines)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Piperazines)
RN  - 1LGS5JRP31 (Nomifensine)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - 90X28IKH43 (vanoxerine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Aging/*physiology
MH  - Amphetamines/pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain Chemistry/drug effects
MH  - Dopamine/*metabolism
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Electrophysiology
MH  - Male
MH  - Methylphenidate/pharmacology
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Neostriatum/drug effects/metabolism
MH  - Nomifensine/pharmacology
MH  - Piperazines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC2957786
EDAT- 2010/07/08 06:00
MHDA- 2010/10/22 06:00
PMCR- 2011/10/01
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - jpet.110.167320 [pii]
AID - 3622934 [pii]
AID - 10.1124/jpet.110.167320 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2010 Oct;335(1):124-32. doi: 10.1124/jpet.110.167320. Epub 
      2010 Jul 6.