PMID- 20606248
OWN - NLM
STAT- MEDLINE
DCOM- 20101006
LR  - 20220309
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 2
IP  - 6
DP  - 2010 Jun
TI  - Regulation of energy metabolism by inflammation: a feedback response in obesity 
      and calorie restriction.
PG  - 361-8
AB  - Caloric restriction (CR), in the absence of malnutrition, delays aging and 
      prevents aging-related diseases through multiple mechanisms. A reduction in 
      chronic inflammation is widely observed in experimental models of caloric 
      restriction. The low inflammation status may contribute to the reduced incidence 
      of osteoporosis, Alzheimer's disease, cardiovascular diseases and cancer in the 
      aging subjects. The association of caloric restriction with low inflammation 
      suggests a role of energy accumulation in the origin of the chronic inflammation. 
      This point is enforced by recent advances in obesity research. Abundant 
      literature on obesity suggests that chronic inflammation is a consequence of 
      energy accumulation in the body. The emerging evidence strongly supports that the 
      inflammatory response induces energy expenditure in a feedback manner to fight 
      against energy surplus in obesity. If this feedback system is deficient 
      (Inflammation Resistance), energy expenditure will be reduced and energy 
      accumulation will lead to obesity. In this perspective, we propose that an 
      increase in inflammation in obesity promotes energy expenditure with a goal to 
      get rid of energy surplus. A decrease in inflammation under caloric restriction 
      contributes to energy saving. Inflammation is a mechanism for energy balance in 
      the body. Inflammation resistance will lead to obesity. We will review the recent 
      literature in support of the viewpoints.
FAU - Ye, Jianping
AU  - Ye J
AD  - Pennington Biomedical Research Center, Louisiana State University System, LA 
      70808, USA.
FAU - Keller, Jeffrey N
AU  - Keller JN
LA  - eng
GR  - R56 DK068036/DK/NIDDK NIH HHS/United States
GR  - R56DK068036-6/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Energy Metabolism/*physiology
MH  - Feedback, Physiological/*physiology
MH  - Humans
MH  - Inflammation/*metabolism/physiopathology
MH  - Obesity/*metabolism/physiopathology
PMC - PMC2919256
COIS- The authors of this manuscript have no conflict of interests to declare.
EDAT- 2010/07/08 06:00
MHDA- 2010/10/07 06:00
PMCR- 2010/06/01
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/10/07 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - v2/n6/full/100155.html [pii]
AID - 10.18632/aging.100155 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2010 Jun;2(6):361-8. doi: 10.18632/aging.100155.