PMID- 20609035
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20200930
IS  - 1365-2761 (Electronic)
IS  - 0140-7775 (Linking)
VI  - 33
IP  - 9
DP  - 2010 Sep
TI  - Pancreas disease (PD) in sea-reared Atlantic salmon, Salmo salar L., in Norway; a 
      prospective, longitudinal study of disease development and agreement between 
      diagnostic test results.
PG  - 723-36
LID - 10.1111/j.1365-2761.2010.01176.x [doi]
AB  - A prospective longitudinal study was performed on three cages at each of three 
      Norwegian Atlantic salmon seawater sites that experienced outbreaks of pancreas 
      disease (PD). Once salmonid alphavirus (SAV) ribonucleic acid (RNA) was detected 
      by real-time RT-PCR (Rt RT-PCR) at a site, it became detected in all studied 
      cages and was persistently found until the end of the study period up to 19 
      months after first detection. SAV-specific antibodies were detected at all sites 
      until the end of the study period and were also found at a high prevalence in 
      broodfish at the time of stripping. No evidence of increased viral activity was 
      detected in these broodfish. One site tested negative over several months prior 
      to the first detection of SAV by Rt RT-PCR and SAV-specific antibody, which 
      occurred 1 month prior to clinical manifestations of PD. Moribund fish or thin 
      fish/runts that were sampled after the first PD diagnosis had almost twice the 
      risk of testing positive by one or more diagnostic tests compared to that of 
      randomly selected apparently healthy individuals. This paper describes the first 
      detailed investigation of the disease development of PD at site and cage level in 
      Norway, as well as an assessment of the performance and agreement of the commonly 
      used diagnostic tests.
FAU - Jansen, M D
AU  - Jansen MD
AD  - Norwegian School of Veterinary Science, Centre for epidemiology and 
      Biostatistics, Oslo, Norway. Mona.Dverdal.Jansen@nvh.no
FAU - Wasmuth, M A
AU  - Wasmuth MA
FAU - Olsen, A B
AU  - Olsen AB
FAU - Gjerset, B
AU  - Gjerset B
FAU - Modahl, I
AU  - Modahl I
FAU - Breck, O
AU  - Breck O
FAU - Haldorsen, R N
AU  - Haldorsen RN
FAU - Hjelmeland, R
AU  - Hjelmeland R
FAU - Taksdal, T
AU  - Taksdal T
LA  - eng
PT  - Journal Article
DEP - 20100629
PL  - England
TA  - J Fish Dis
JT  - Journal of fish diseases
JID - 9881188
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Alphavirus/physiology
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Fish Diseases/*diagnosis/*pathology/virology
MH  - Longitudinal Studies
MH  - Norway
MH  - Pancreatic Diseases/diagnosis/pathology/*veterinary/virology
MH  - Reproducibility of Results
MH  - Reverse Transcriptase Polymerase Chain Reaction/veterinary
MH  - Salmo salar/*virology
EDAT- 2010/07/09 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - JFD1176 [pii]
AID - 10.1111/j.1365-2761.2010.01176.x [doi]
PST - ppublish
SO  - J Fish Dis. 2010 Sep;33(9):723-36. doi: 10.1111/j.1365-2761.2010.01176.x. Epub 
      2010 Jun 29.