PMID- 20609265
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20211203
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 104
IP  - 10
DP  - 2010 Nov
TI  - Effects of different dietary protein sources on expression of genes related to 
      protein metabolism in growing rats.
PG  - 1421-8
LID - 10.1017/S000711451000231X [doi]
AB  - Protein metabolism is known to be affected by dietary proteins, but the 
      fundamental mechanisms that underlie the changes in protein metabolism are 
      unclear. The aim of the present study was to test the effects of feeding growing 
      rats with balanced diets containing soya protein isolate, zein and casein as the 
      sole protein source on the expression of genes related to protein metabolism 
      responses in skeletal muscle. The results showed that feeding a zein protein diet 
      to the growing rats induced changes in protein anabolic and catabolic metabolism 
      in their gastrocnemius muscles when compared with those fed either the reference 
      protein casein diet or the soya protein isolate diet. The zein protein diet 
      increased not only the mRNA levels and phosphorylation of mammalian target of 
      rapamycin (mTOR), but also the mRNA expression of muscle atrophy F-box 
      (MAFbx)/atrogin-1 and muscle ring finger 1 (MuRF1), as well as the forkhead box-O 
      (FoxO) transcription factors involved in the induction of the E3 ligases. The 
      amino acid profile of proteins seems to control signalling pathways leading to 
      changes in protein synthesis and proteolysis.
FAU - Luo, Junqiu
AU  - Luo J
AD  - Institute of Animal Nutrition, Sichuan Agricultural University, Xinkang Road 46, 
      Ya'an, Sichuan 625014, People's Republic of China.
FAU - Chen, Daiwen
AU  - Chen D
FAU - Yu, Bing
AU  - Yu B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100708
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Caseins)
RN  - 0 (Dietary Proteins)
RN  - 0 (Proteins)
RN  - 0 (Soybean Proteins)
RN  - 9010-66-6 (Zein)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Caseins/administration & dosage/chemistry
MH  - Dietary Proteins/administration & dosage/analysis/*pharmacology
MH  - Gene Expression Regulation, Developmental/*drug effects
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - Phosphorylation
MH  - Proteins/*metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Soybean Proteins/administration & dosage/chemistry
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Zein/administration & dosage/chemistry
EDAT- 2010/07/09 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - S000711451000231X [pii]
AID - 10.1017/S000711451000231X [doi]
PST - ppublish
SO  - Br J Nutr. 2010 Nov;104(10):1421-8. doi: 10.1017/S000711451000231X. Epub 2010 Jul 
      8.