PMID- 20609420
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20100809
IS  - 1873-0329 (Electronic)
IS  - 1383-5769 (Linking)
VI  - 59
IP  - 3
DP  - 2010 Sep
TI  - Characterization of immune responses to single or mixed infections with P. yoelii 
      17XL and P. chabaudi AS in different strains of mice.
PG  - 400-6
LID - 10.1016/j.parint.2010.05.005 [doi]
AB  - The outcome of Plasmodium yoelii 17XL (P.y17XL)-infected BALB/c and DBA/2 mice, 
      ranging from death to spontaneous cure, depends largely on the establishment of 
      effective Th1 and Th2 responses and a successful switch between Th1 and Th2 
      responses, as well as appropriate functioning of CD4(+)CD25(+)Foxp3(+)regulatory 
      T cells (Tregs). The infection with another malaria-causing parasite, Plasmodium 
      chabaudi AS (P.cAS), leads to a different outcome in BALB/c and DBA/2 mice 
      compared to mice infected with P.y17XL alone. To understand the consequence of 
      co-infection with P.y17XL and P.cAS, we determined the proliferation curve of 
      parasites, pro-inflammatory/anti-inflammatory cytokine profiles, and the dynamic 
      changes of the number of Tregs in DBA/2 and BALB/c mice with single or 
      mixed-species infections. The infective mode in mixed-species infections was the 
      same as single P.y17XL infections. The multiplication of P.y17XL parasites 
      prevailed in BALB/c and DBA/2 mice with early mixed infections, as detected by 
      RTQ-PCR. Subsequently, the multiplication of P.cAS parasites dominated in DBA/2 
      mice with mixed infections, while BALB/c mice succumbed to infection. In 
      addition, the dynamic changes in IFN-gamma and IL-4 production in mice with mixed 
      infections, used as a measure of Th1 and Th2 responsiveness, were consistent with 
      P.y17XL-infected mice. Treg activation and the IL-10 level were also closely 
      related to susceptibility to infection. Our findings demonstrate that the 
      characteristics of the immune response during infections with mixed species are 
      dependent on the mode of proliferation of different species of Plasmodium. 
      Indeed, different species of Plasmodium can influence each other in the same 
      host.
FAU - Chen, Guang
AU  - Chen G
AD  - Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Heping District, Shenyang, China.
FAU - Feng, Hui
AU  - Feng H
FAU - Liu, Jun
AU  - Liu J
FAU - Qi, Zan-mei
AU  - Qi ZM
FAU - Wu, Yi
AU  - Wu Y
FAU - Guo, Sheng-yu
AU  - Guo SY
FAU - Li, Dong-mei
AU  - Li DM
FAU - Wang, Ji-chun
AU  - Wang JC
FAU - Cao, Ya-ming
AU  - Cao YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100604
PL  - Netherlands
TA  - Parasitol Int
JT  - Parasitology international
JID - 9708549
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Female
MH  - Inflammation/immunology
MH  - Malaria/*immunology/*parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred DBA
MH  - Plasmodium chabaudi/*immunology/pathogenicity
MH  - Plasmodium yoelii/*immunology/pathogenicity
MH  - Species Specificity
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
EDAT- 2010/07/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/09 06:00
PHST- 2009/11/15 00:00 [received]
PHST- 2010/05/03 00:00 [revised]
PHST- 2010/05/20 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1383-5769(10)00094-2 [pii]
AID - 10.1016/j.parint.2010.05.005 [doi]
PST - ppublish
SO  - Parasitol Int. 2010 Sep;59(3):400-6. doi: 10.1016/j.parint.2010.05.005. Epub 2010 
      Jun 4.