PMID- 20613458
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20211020
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 24
IP  - 13
DP  - 2010 Aug 24
TI  - Association between HLA inheritance and asthma medication use in HIV positive 
      children.
PG  - 2133-5
LID - 10.1097/QAD.0b013e32833cba08 [doi]
AB  - This study's purpose was to determine whether asthma medication use in HIV 
      positive children is associated with human leukocyte antigen (HLA) alleles. We 
      reviewed HLA and medication data collected during the Women and Infants 
      Transmission Study for 124 HIV positive children and their mothers. Analysis 
      revealed that HLA-A68 (P = 0.006) was independent and predictive for time to 
      first asthma medication use. There was a preventive association of Cw6 (P = 
      0.008) with asthma time. Highly active antiretroviral therapy (HAART) was also 
      associated with time to first asthma medication use (P = 0.05). HLA alleles may 
      modulate risk of developing a need for asthma medications and seem to function 
      independently of the actions of HAART therapy.
FAU - Foster, Samuel B
AU  - Foster SB
AD  - Baylor College of Medicine and Texas Children's Hospital, Department of 
      Pediatrics, Allergy and Immunology Section, Houston, Texas, USA.
FAU - Lu, Ming
AU  - Lu M
FAU - Thompson, Bruce
AU  - Thompson B
FAU - Rich, Kenneth C
AU  - Rich KC
FAU - Matukas, Larissa M
AU  - Matukas LM
FAU - Mason, Rosemarie
AU  - Mason R
FAU - Winchester, Robert
AU  - Winchester R
FAU - MacDonald, Kelly S
AU  - MacDonald KS
FAU - Shearer, William T
AU  - Shearer WT
LA  - eng
GR  - R01 HL079533/HL/NHLBI NIH HHS/United States
GR  - M01 RR000188/RR/NCRR NIH HHS/United States
GR  - ROGB162/CAPMC/CIHR/Canada
GR  - AI36211/AI/NIAID NIH HHS/United States
GR  - U01 HD041983/HD/NICHD NIH HHS/United States
GR  - U01 AI050274/AI/NIAID NIH HHS/United States
GR  - HL079533/HL/NHLBI NIH HHS/United States
GR  - L40 AI071576-02/AI/NIAID NIH HHS/United States
GR  - AI050274-05/AI/NIAID NIH HHS/United States
GR  - HD41983/HD/NICHD NIH HHS/United States
GR  - K01 RR000188/RR/NCRR NIH HHS/United States
GR  - P30 AI036211/AI/NIAID NIH HHS/United States
GR  - RR0188/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antiretroviral Therapy, Highly Active
MH  - Asthma/drug therapy/*immunology
MH  - Child
MH  - HIV Infections/drug therapy/*immunology
MH  - *HIV-1
MH  - HLA Antigens/drug effects/*immunology
MH  - Humans
PMC - PMC3665405
MID - NIHMS221828
COIS- Conflicts of interest: None of the authors reports a potential conflict of 
      interest.
EDAT- 2010/07/09 06:00
MHDA- 2011/03/26 06:00
PMCR- 2013/05/28
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
PHST- 2013/05/28 00:00 [pmc-release]
AID - 10.1097/QAD.0b013e32833cba08 [doi]
PST - ppublish
SO  - AIDS. 2010 Aug 24;24(13):2133-5. doi: 10.1097/QAD.0b013e32833cba08.