PMID- 20614267
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20211020
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 1
IP  - 2
DP  - 2007 Dec
TI  - Plasmablastic lymphoma of head and neck: report of two new cases and correlation 
      with c-myc and IgVH gene mutation status.
PG  - 150-5
LID - 10.1007/s12105-007-0006-5 [doi]
AB  - Plasmablastic lymphoma (PBL) is a rare acquired immunodeficiency 
      syndrome-associated non-Hodgkin's lymphoma (AIDS-NHL), with predilection for the 
      mucosa of oral cavity. It usually has a plasmablastic morphology, expressing 
      plasma cell-associated antigens with weak or absent expression of 
      B-cell-associated markers. To further define the immunophenotypic and molecular 
      genetics of these tumors, we investigated two cases of plasmablastic lymphomas of 
      the head and neck for c-myc gene rearrangement and immunoglobulin heavy chain 
      (IgV(H)) hypermutation status. For the first time we report a case of 
      AIDS-related PBL that, by fluorescence in situ hybridization (FISH), shows a 
      c-myc gene rearrangement. Although current literature suggests that most cases of 
      c-myc gene rearranged AIDS-NHL are Burkitt's lymphoma, our case has an 
      immunophenotype characteristic for PBL. In this case, IgV(H) hypermutation 
      analysis showed a somatic hypermutation, indicative of germinal center transit. 
      The concurrent B-cell immunophenotype of BCL-6(-)/CD138(+)/MUM-1(+) also suggests 
      a post-germinal center B-cell origin of this lymphoma. The immunophenotype of our 
      second case (BCL-6(-)/CD138(+)/MUM-1(+)) also suggests a post-germinal center 
      B-cell origin. However, IgV(H) hypermutation analysis was not possible in this 
      case.
FAU - Hassan, Anjum
AU  - Hassan A
AD  - Department of Pathology and Immunology, Division of Anatomic Pathology, 
      Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO 
      63110, USA. ahassan@path.wustl.edu
FAU - Kreisel, Friederike
AU  - Kreisel F
FAU - Gardner, Laura
AU  - Gardner L
FAU - Lewis, James S Jr
AU  - Lewis JS Jr
FAU - El-Mofty, Samir K
AU  - El-Mofty SK
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20071026
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Immunoglobulin Variable Region)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Gene Rearrangement, B-Lymphocyte
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics/immunology
MH  - Immunoglobulin Variable Region/*genetics/immunology
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, AIDS-Related/genetics/immunology/*pathology
MH  - Lymphoma, Large-Cell, Immunoblastic/genetics/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/genetics/immunology/*pathology
MH  - Mutation
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Somatic Hypermutation, Immunoglobulin/genetics/immunology
PMC - PMC2807524
OTO - NOTNLM
OT  - Acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma
OT  - Immunoglobulin variable heavy chain hypermutation status
OT  - Plasmablastic lymphoma
OT  - c-myc gene rearrangement
EDAT- 2007/12/01 00:00
MHDA- 2010/10/06 06:00
PMCR- 2007/12/01
CRDT- 2010/07/09 06:00
PHST- 2007/02/27 00:00 [received]
PHST- 2007/04/27 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2007/12/01 00:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
PHST- 2007/12/01 00:00 [pmc-release]
AID - 6 [pii]
AID - 10.1007/s12105-007-0006-5 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2007 Dec;1(2):150-5. doi: 10.1007/s12105-007-0006-5. Epub 2007 
      Oct 26.