PMID- 20614344
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 0179-5953 (Print)
IS  - 0179-5953 (Linking)
VI  - 193
DP  - 2008
TI  - Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk 
      Assessment.
PG  - 53-212
LID - 10.1007/978-0-387-73163-6_3 [doi]
AB  - Our interest in providing parameters for the development of quantitative 
      structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) 
      models for assessing health risks to carbamates (USEPA 2005) comes from earlier 
      work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters 
      specific to each carbamate are needed in the construction of PBPK/PD models along 
      with their metabolic pathways. Parameters may be obtained by (1) development of 
      QSAR models, (2) collecting pharmacokinetic data, and (3) determining 
      pharmacokinetic parameters by fitting to experimental data. The biological 
      parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological 
      Parameters Required for Carbamate Pesticide Physiologically Based 
      Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.(a).
FAU - Knaak, James B
AU  - Knaak JB
AD  - Department of Pharmacology and Toxicology, School of Medicine and Biomedical 
      Sciences, SUNY at Buffalo, 3435 Main Street, Buffalo, NY, 14214, USA.
FAU - Dary, Curt C
AU  - Dary CC
FAU - Okino, Miles S
AU  - Okino MS
FAU - Power, Fred W
AU  - Power FW
FAU - Zhang, Xiaofei
AU  - Zhang X
FAU - Thompson, Carol B
AU  - Thompson CB
FAU - Tornero-Velez, R
AU  - Tornero-Velez R
FAU - Blancato, Jerry N
AU  - Blancato JN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rev Environ Contam Toxicol
JT  - Reviews of environmental contamination and toxicology
JID - 8703602
RN  - 0 (Carbamates)
RN  - 0 (Insecticides)
RN  - 0 (Pesticides)
SB  - IM
MH  - Carbamates
MH  - Humans
MH  - Insecticides/chemistry
MH  - *Models, Biological
MH  - Pesticides
MH  - *Quantitative Structure-Activity Relationship
MH  - Risk Assessment
EDAT- 2008/01/01 00:00
MHDA- 2016/04/24 06:00
CRDT- 2010/07/09 06:00
PHST- 2007/04/16 00:00 [received]
PHST- 2007/04/21 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 10.1007/978-0-387-73163-6_3 [doi]
PST - ppublish
SO  - Rev Environ Contam Toxicol. 2008;193:53-212. doi: 10.1007/978-0-387-73163-6_3.