PMID- 20614847
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20211020
IS  - 0161-8105 (Print)
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Linking)
VI  - 33
IP  - 7
DP  - 2010 Jul
TI  - Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy.
PG  - 875-8
AB  - STUDY OBJECTIVES: Narcolepsy is a sleep disorder characterized by excessive 
      daytime sleepiness and cataplexy. The association with human leukocyte antigen 
      (HLA)-DQB1*0602 and T-cell receptor alpha locus suggests that autoimmunity plays 
      a role in narcolepsy. A recent study reported an increased prevalence of 
      autoantibodies against Tribbles homolog 2 (TRIB2) in patients with narcolepsy. To 
      replicate this finding, we examined anti-TRIB2 autoantibodies in Japanese 
      patients with narcolepsy. DESIGN: We examined anti-TRIB2 autoantibodies against a 
      full-length [35S]-labeled TRIB2 antigen in Japanese patients with 
      narcolepsy-cataplexy (n = 88), narcolepsy without cataplexy (n = 18), and 
      idiopathic hypersomnia with long sleep time (n = 11). The results were compared 
      to Japanese healthy controls (n = 87). Thirty-seven healthy control subjects were 
      positive for HLA-DRB1*1501-DQB1*0602. We also examined autoantibodies against 
      another Tribbles homolog, TRIB3, as an experimental control. MEASUREMENTS AND 
      RESULTS: Autoantibodies against TRIB2 were found in 26.1% of patients with 
      narcolepsy-cataplexy, a significantly higher prevalence than the 2.3% in healthy 
      controls. We found that anti-TRIB3 autoantibodies were rare in patients with 
      narcolepsy and showed no association with anti-TRIB2 indices. No significant 
      correlation was found between anti-TRIB2 positivity and clinical information. 
      CONCLUSIONS: We confirmed the higher prevalence and specificity of anti-TRIB2 
      autoantibodies in Japanese patients with narcolepsy-cataplexy. This suggests a 
      subgroup within narcolepsy-cataplexy might be affected by an anti-TRIB2 
      autoantibody-mediated autoimmune mechanism.
FAU - Toyoda, Hiromi
AU  - Toyoda H
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Tanaka, Susumu
AU  - Tanaka S
FAU - Miyagawa, Taku
AU  - Miyagawa T
FAU - Honda, Yutaka
AU  - Honda Y
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
FAU - Honda, Makoto
AU  - Honda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (Autoantibodies)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.17 (TRIB2 protein, human)
SB  - IM
CIN - Sleep. 2010 Jul;33(7):857-8. PMID: 20614841
MH  - Adult
MH  - Autoantibodies/*immunology
MH  - Autoimmunity/*immunology
MH  - Calcium-Calmodulin-Dependent Protein Kinases
MH  - Female
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*immunology
MH  - Japan
MH  - Male
MH  - Narcolepsy/*immunology
MH  - Radioligand Assay/methods
PMC - PMC2894429
EDAT- 2010/07/10 06:00
MHDA- 2010/07/31 06:00
PMCR- 2011/01/01
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 10.1093/sleep/33.7.875 [doi]
PST - ppublish
SO  - Sleep. 2010 Jul;33(7):875-8. doi: 10.1093/sleep/33.7.875.