PMID- 20615325
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20161020
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 31
IP  - 3
DP  - 2010 May-Jun
TI  - The role of atopy in the clinical course of pulmonary sarcoidosis in the Japanese 
      population.
PG  - 238-43
LID - 10.2500/aap.2010.31.3336 [doi]
AB  - Sarcoidosis is a multisystem disorder characterized by a T-helper 1 
      (Th1)-mediated immune response. Conversely, atopy is characterized by the 
      presence of a specific immunoglobulin E (IgE) E response in association with a 
      Th2-type immune response. Several epidemiological studies have shown that atopic 
      status influences disease activity and clinical course for several Th1-mediated 
      diseases. The aim of this study was to evaluate associations between atopic 
      status and clinical findings of sarcoidosis. We further evaluated the impact of 
      atopic status on the clinical course of pulmonary sarcoidosis. We defined atopy 
      as a positive specific IgE response to at least one common inhaled allergen 
      (multiple antigen simultaneous test scores, lumicount of >1.01). Subjects 
      comprised 134 patients given a diagnosis of sarcoidosis between 2000 and 2006, 
      divided into atopic and nonatopic groups. Several clinical findings were compared 
      between the two groups. Furthermore, 100 subjects observed 2 years after 
      diagnosis were divided into resolving and persistent clinical course groups 
      according to chest radiography and associations with atopic status were 
      evaluated. Atopy was more prevalent among men than women (p = 0.009) and subjects 
      with atopy were younger (p = 0.002) and showed less frequent lung parenchymal 
      lesions (stages II and III; p = 0.018) compared with subjects without atopy. The 
      prevalence of atopy was higher in the resolving clinical course group than in the 
      persistent clinical course group (p = 0.002) and this association was independent 
      of sex, age, presence of lung parenchymal lesions, and presence of extrapulmonary 
      lesions (p = 0.037). Classification of sarcoidosis based on atopic status might 
      be useful for predicting the clinical course of pulmonary sarcoidosis.
FAU - Hattori, Takeshi
AU  - Hattori T
AD  - First Department of Medicine, Hokkaido University School of Medicine, Sapporo, 
      Japan.
FAU - Konno, Satoshi
AU  - Konno S
FAU - Takahashi, Ayumu
AU  - Takahashi A
FAU - Isada, Akira
AU  - Isada A
FAU - Shigemura, Masahiko
AU  - Shigemura M
FAU - Matsuno, Kazuhiko
AU  - Matsuno K
FAU - Shimizu, Chikara
AU  - Shimizu C
FAU - Hizawa, Nobuyuki
AU  - Hizawa N
FAU - Yamaguchi, Etsuro
AU  - Yamaguchi E
FAU - Nishimura, Masaharu
AU  - Nishimura M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Allergens/immunology/*metabolism
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sarcoidosis, Pulmonary/blood/diagnosis/*epidemiology/*physiopathology
MH  - Sex Factors
EDAT- 2010/07/10 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.2500/aap.2010.31.3336 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2010 May-Jun;31(3):238-43. doi: 10.2500/aap.2010.31.3336.