PMID- 20615731
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20220309
IS  - 1532-2149 (Electronic)
IS  - 1090-3801 (Linking)
VI  - 15
IP  - 2
DP  - 2011 Feb
TI  - Diffuse noxious inhibitory control evoked by tonic craniofacial pain in humans.
PG  - 139-45
LID - 10.1016/j.ejpain.2010.06.009 [doi]
AB  - Tonic pain in one body segment can inhibit the perception of pain in another body 
      segment. This phenomenon is mediated by diffuse noxious inhibitory controls 
      (DNIC), and its efficacy in craniofacial regions is investigated in this study. A 
      compressive device that evoked a tonic, moderate/severe, headache-like, 
      conditioning pain ( approximately 8/10 on a visual analogue scale) was applied for 15min. 
      Eleven males participated in the study. Pressure pain threshold (PPT) and 
      pressure pain tolerance (PPTol) at multiple heterosegmental body sites (right 
      masseter, splenius capitis, second intermediate phalange, brachioradialis and 
      tibialis anterior) were measured before, during and at multiple time points (5, 
      20 and 35min) after the termination of the conditioning pain. PPTs and PPTols 
      were compared within participants across two experimental sessions; one that 
      included painful conditioning stimulation, and a separate control session on a 
      different day. Painful conditioning increased PPT significantly during pain over 
      the masseter (p<0.05) and over the tibialis anterior (p<0.01). PPTol was 
      unchanged. In the period after the painful conditioning stimulation PPT was 
      depressed compared to control. This study shows that pain evoked from the 
      craniofacial region evokes DNIC-like mechanisms on segmental as well as 
      heterosegmental sites.
CI  - Copyright (c) 2010 European Federation of International Association for the Study 
      of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
FAU - Sowman, P F
AU  - Sowman PF
AD  - Macquarie Centre for Cognitive Science (MACCS), Macquarie University, Sydney, 
      Australia.
FAU - Wang, K
AU  - Wang K
FAU - Svensson, P
AU  - Svensson P
FAU - Arendt-Nielsen, L
AU  - Arendt-Nielsen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100707
PL  - England
TA  - Eur J Pain
JT  - European journal of pain (London, England)
JID - 9801774
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Facial Pain/*physiopathology
MH  - Humans
MH  - Male
MH  - Neural Inhibition/*physiology
MH  - Pain Measurement
MH  - Pain Perception/*physiology
MH  - Pain Threshold/*physiology
MH  - Physical Stimulation
EDAT- 2010/07/10 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/04/07 00:00 [received]
PHST- 2010/06/02 00:00 [revised]
PHST- 2010/06/08 00:00 [accepted]
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - S1090-3801(10)00142-4 [pii]
AID - 10.1016/j.ejpain.2010.06.009 [doi]
PST - ppublish
SO  - Eur J Pain. 2011 Feb;15(2):139-45. doi: 10.1016/j.ejpain.2010.06.009. Epub 2010 
      Jul 7.