PMID- 20616147
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20221207
IS  - 1464-3804 (Electronic)
IS  - 0267-8357 (Linking)
VI  - 25
IP  - 5
DP  - 2010 Sep
TI  - Low-dose persistent organic pollutants increased telomere length in peripheral 
      leukocytes of healthy Koreans.
PG  - 511-6
LID - 10.1093/mutage/geq035 [doi]
AB  - Although shortened telomeres have been found in many cancers, elongated telomere 
      length has been observed as an early response after low-dose treatment with 
      various chemical carcinogens in vitro and animal experiments, suggesting low-dose 
      exposure to carcinogenic chemicals may function as a tumour promoter at the very 
      early stage of carcinogenesis in humans. This cross-sectional study was performed 
      to examine whether low-dose exposure to persistent organic pollutants (POPs), 
      lipophilic xenobiotics that mainly bioaccumulate in adipose tissue, is associated 
      with telomere length of peripheral blood leukocytes in apparently healthy 
      persons. Telomere length was measured using quantitative polymerase chain 
      reaction method in 84 apparently healthy Koreans. Among various POPs, serum 
      concentrations of organochlorine (OC) pesticides, polychlorinated biphenyls 
      (PCBs) and polybrominated diphenylethers were measured. Most OC pesticides and 
      PCBs were positively and significantly associated with telomere length with 
      correlation coefficients from about +0.25 to +0.35. The strongest associations 
      were observed with p,p'-dichlorodiphenyldichloroethylene, PCB99, PCB153, PCB180, 
      PCB183 and PCB187. When we examined adjusted means of telomere length by 
      quintiles of POPs, the steeper increases of telomere length tended to be observed 
      within relatively lower ranges of POPs. Besides serum concentrations of POPs, 
      none of the other variables studied, including age, were associated with telomere 
      length in this study. We found that telomere length was increasing across low 
      doses of exposure to POPs in which the majority of study subjects were found, 
      suggesting that low-dose POPs may act as a tumour promoter in carcinogenesis in 
      humans.
FAU - Shin, Ji-Yeon
AU  - Shin JY
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 101 Dongin-dong, Jung-gu, Daegu, 700-422 Korea.
FAU - Choi, Yi Young
AU  - Choi YY
FAU - Jeon, Hyo-Sung
AU  - Jeon HS
FAU - Hwang, Jun-Hyun
AU  - Hwang JH
FAU - Kim, Sung-Ae
AU  - Kim SA
FAU - Kang, Jung-Ho
AU  - Kang JH
FAU - Chang, Yoon-Seok
AU  - Chang YS
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
FAU - Park, Jae Yong
AU  - Park JY
FAU - Lee, Duk-Hee
AU  - Lee DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100708
PL  - England
TA  - Mutagenesis
JT  - Mutagenesis
JID - 8707812
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - *Asian People
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - *Health
MH  - Humans
MH  - Leukocytes/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Organic Chemicals/*blood
MH  - Polychlorinated Biphenyls/blood
MH  - Republic of Korea
MH  - Statistics, Nonparametric
MH  - Telomere/*metabolism
EDAT- 2010/07/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - geq035 [pii]
AID - 10.1093/mutage/geq035 [doi]
PST - ppublish
SO  - Mutagenesis. 2010 Sep;25(5):511-6. doi: 10.1093/mutage/geq035. Epub 2010 Jul 8.