PMID- 20616549
OWN - NLM
STAT- MEDLINE
DCOM- 20110801
LR  - 20161125
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 116
IP  - 3
DP  - 2010
TI  - Long-term follow-up of the first patients to undergo transcatheter alcohol septal 
      ablation.
PG  - 168-73
LID - 10.1159/000318307 [doi]
AB  - We describe the 10-year outcome of the first-in-human series of 12 patients with 
      hypertrophic cardiomyopathy treated with alcohol septal ablation. There was no 
      30-day mortality. Survival free of death, internal cardiac defibrillator 
      discharge for treatment of ventricular fibrillation or tachycardia, severe New 
      York Heart Association (NYHA) class III/IV and/or Canadian Cardiovascular Society 
      class III/IV symptoms and the need for surgical myectomy in this cohort was 91% 
      at 1 year and 73% at 10 years. The reduction in outflow tract gradient was 
      maintained over the 10 years, from a mean preoperative gradient of 70 mm Hg to a 
      median of 3 mm Hg at 126 months of follow-up (p < 0.01). Two patients (16%) 
      underwent a further ablation procedure. Two patients (16%) suffered sudden 
      cardiac death, 91 and 102 months after the procedure. Long-term symptom benefit 
      was experienced by all patients, with a reduction in mean NYHA class from 2.7 +/- 
      0.6 before the procedure to 1 after the procedure at the last follow-up (p < 
      0.01). This historic small cohort study demonstrates that septal ablation can 
      provide long-term haemodynamic and symptomatic benefit.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Lyne, J C
AU  - Lyne JC
AD  - Department of Cardiology, Royal Brompton Hospital, London, UK. j.lyne@rbht.nhs.uk
FAU - Kilpatrick, T
AU  - Kilpatrick T
FAU - Duncan, A
AU  - Duncan A
FAU - Knight, C J
AU  - Knight CJ
FAU - Sigwart, U
AU  - Sigwart U
FAU - Fox, K M
AU  - Fox KM
LA  - eng
PT  - Journal Article
DEP - 20100709
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - 0 (Alcohols)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alcohols
MH  - Cardiomyopathy, Hypertrophic/diagnostic imaging/mortality/*surgery
MH  - Catheter Ablation/*methods
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Septum/*surgery
MH  - Humans
MH  - London/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/07/10 06:00
MHDA- 2011/08/02 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/01/29 00:00 [received]
PHST- 2010/03/29 00:00 [accepted]
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2011/08/02 06:00 [medline]
AID - 000318307 [pii]
AID - 10.1159/000318307 [doi]
PST - ppublish
SO  - Cardiology. 2010;116(3):168-73. doi: 10.1159/000318307. Epub 2010 Jul 9.