PMID- 20616755
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20161125
IS  - 1473-5598 (Electronic)
IS  - 0263-6352 (Linking)
VI  - 28
IP  - 10
DP  - 2010 Oct
TI  - Assessment of target-organ damage in adolescent white-coat and sustained 
      hypertensives.
PG  - 2139-44
LID - 10.1097/HJH.0b013e32833cd2da [doi]
AB  - AIMS AND SCOPE: The aim of the present study was to assess whether a difference 
      exists between intima-media thickness and the left ventricular mass index in 
      healthy nonhypertensive, white-coat hypertensive and sustained hypertensive 
      adolescents. PATIENTS AND METHODS: Fifty-nine normotensive and 120 hypertensive 
      adolescents were enrolled in our study. Hypertensive patients were classified 
      into white-coat hypertension (WCH) and sustained hypertension groups based on 
      24-h ambulatory blood pressure measurements. Both normotensive and hypertensive 
      individuals underwent routine laboratory tests, intima-media thickness 
      measurements on the common carotid arteries and transthoracic echocardiography to 
      measure the left ventricular mass index (LVMI). RESULTS: Intima-media thickness 
      was higher both in WCH and sustained hypertension compared with healthy 
      normotensive individuals (controls: 0.048 +/- 0.01 cm, WCH: 0.056 +/- 0.01 cm, 
      sustained hypertension: 0.054 +/- 0.012 cm, both P < 0.001 compared with controls, 
      nonsignificant difference between the two hypertensive groups). There was no 
      difference between the LVMI of control individuals and WCH (LVMI: 35.5 +/- 10.3 g/m 
      and 37.7 +/- 11.2 g/m respectively, P = 0.87). LVMI in sustained hypertension group 
      (LVMI: 44.1 +/- 14.1 g/m) was significantly higher both compared with WCH (P < 
      0.05), and healthy adolescents (P < 0.001). CONCLUSION: Target-organ damage 
      develops in a stepwise fashion in adolescent hypertension. An increased 
      intima-media thickness can be demonstrated not only in the sustained but also in 
      the white-coat form of adolescent hypertension.
FAU - Pall, Denes
AU  - Pall D
AD  - First Department of Medicine, University of Debrecen, Debrecen, Hungary.
FAU - Juhasz, Maria
AU  - Juhasz M
FAU - Lengyel, Szabolcs
AU  - Lengyel S
FAU - Molnar, Csilla
AU  - Molnar C
FAU - Paragh, Gyorgy
AU  - Paragh G
FAU - Fulesdi, Bela
AU  - Fulesdi B
FAU - Katona, Eva
AU  - Katona E
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
SB  - IM
MH  - Adolescent
MH  - Blood Pressure/physiology
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Carotid Arteries/diagnostic imaging/*pathology
MH  - Case-Control Studies
MH  - Echocardiography
MH  - Female
MH  - Heart Ventricles/diagnostic imaging/*pathology
MH  - Humans
MH  - Hypertension/epidemiology/*pathology/physiopathology
MH  - Male
MH  - *Office Visits
MH  - Prevalence
MH  - Tunica Intima/diagnostic imaging/*pathology
MH  - Tunica Media/diagnostic imaging/*pathology
EDAT- 2010/07/10 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1097/HJH.0b013e32833cd2da [doi]
PST - ppublish
SO  - J Hypertens. 2010 Oct;28(10):2139-44. doi: 10.1097/HJH.0b013e32833cd2da.