PMID- 20617689
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20220316
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 35
IP  - 8
DP  - 2010 Apr
TI  - [Study on fingerprints correlated with pharmacodynamic of constituents in Herba 
      Erigerontis against neurotoxicity induced by beta-amyloid peptide].
PG  - 1038-41
AB  - OBJECTIVE: To investigate the neuroprotective effects of the constituents in 
      Herba Erigerontis on neuroblastoma SH-SY5Y cells, and find out its possible 
      material foundation in treating Alzheimer's disease (AD). METHOD: Different 
      combinations of the three constituents in Herba Erigerontis were prepared 
      according to the orthogonality experiment, and the indexes (MTT reduction assay, 
      lipid peroxidation and expressions of nAChR alpha7 protein)were observed upon the 
      SH-SY5Y cells followed by treatment of these combinations and beta-amyloid 
      peptide (AP). The pharmacology data thus obtained and peak data in UPLC 
      fingerprint were analyzed through ANOVA and correlationship by SPSS to give the 
      information of active possible material foundation. RESULT: Constituents B and C 
      showed clear activity and peaks of 4, 7-12 did positive correlationship according 
      to the correlation of fingerprints and pharmacology. CONCLUSION: This study makes 
      a valid approach for deducing the active constituents even the exact compounds 
      against neurotoxicity induced by Abeta by correlation of fingerprints and 
      pharmacology.
FAU - Huang, Yong
AU  - Huang Y
AD  - School of Pharmacy, Guiyang Medical College, Guiyang 550004, China.
FAU - Qi, Xiaolan
AU  - Qi X
FAU - Guan, Zhizhong
AU  - Guan Z
FAU - Wang, Yonglin
AU  - Wang Y
FAU - Wang, Aimin
AU  - Wang A
FAU - Li, Cuibing
AU  - Li C
FAU - Chi, Mingyan
AU  - Chi M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Neurotoxins)
SB  - IM
MH  - Alzheimer Disease/drug therapy
MH  - Amyloid beta-Peptides/*toxicity
MH  - Analysis of Variance
MH  - Animals
MH  - Cell Line, Tumor
MH  - Chromatography, High Pressure Liquid
MH  - Drugs, Chinese Herbal/*chemistry/*pharmacology/therapeutic use
MH  - Erigeron/*chemistry
MH  - Humans
MH  - Nervous System/*drug effects
MH  - Neurotoxins/*toxicity
EDAT- 2010/07/14 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - 10.4268/cjcmm20100822 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2010 Apr;35(8):1038-41. doi: 10.4268/cjcmm20100822.