PMID- 20618390
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20220409
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 28
IP  - 1
DP  - 2011 Jan
TI  - Fragmented QRS complexes are associated with cardiac fibrosis and significant 
      intraventricular systolic dyssynchrony in nonischemic dilated cardiomyopathy 
      patients with a narrow QRS interval.
PG  - 62-8
LID - 10.1111/j.1540-8175.2010.01242.x [doi]
AB  - BACKGROUND: Myocardial scar causes heterogeneous ventricular activation, which 
      results in fragmentation of QRS complexes on ECG. Myocardial fibrosis in patients 
      with nonischemic cardiomyopathy (NDCM) can be identified as late gadolinium 
      enhancement (LGE) areas on cardiac magnetic resonance (CMR) studies. We 
      investigated the association of fragmented QRS (fQRS) complexes with systolic 
      dyssynchrony and myocardial fibrosis in patients with NDCM. METHODS: Twenty 
      patients with NDCM and sinus rhythm who had fQRS complexes were evaluated with 
      CMR. The association of fQRS complexes with LGE and systolic dyssynchrony was 
      investigated. RESULTS: Nineteen patients had significant systolic dyssynchrony 
      with echocardiography. Among 19 patients with significant dyssynchrony, 14 (74%) 
      patients had fQRS complexes in the most delayed contracting segment or one of the 
      dyssynchronous segments, whereas five patients (26%) had fQRS complexes in a lead 
      which is discordant with the dyssynchronous segment on echocardiography. 
      Seventeen patients had LGE in their CMR. Among the 17 patients with LGE; 13 
      patients (76%) had fQRS complexes concordant with LGE present segments. 
      CONCLUSION: Fragmentation of QRS complexes on ECG is associated with 
      intraventricular systolic dyssynchrony and subendocardial fibrosis in NDCM 
      patients with a narrow QRS interval and sinus rhythm.
CI  - (c) 2010, Wiley Periodicals, Inc.
FAU - Basaran, Yelda
AU  - Basaran Y
AD  - Cardiology Department, Kartal Kosuyolu Heart Education and Research Hospital, 
      Istanbul, Turkey. mktigen@yahoo.com
FAU - Tigen, Kursat
AU  - Tigen K
FAU - Karaahmet, Tansu
AU  - Karaahmet T
FAU - Isiklar, Iclal
AU  - Isiklar I
FAU - Cevik, Cihan
AU  - Cevik C
FAU - Gurel, Emre
AU  - Gurel E
FAU - Dundar, Cihan
AU  - Dundar C
FAU - Pala, Selcuk
AU  - Pala S
FAU - Mahmutyazicioglu, Kamran
AU  - Mahmutyazicioglu K
FAU - Basaran, Ozcan
AU  - Basaran O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/diagnosis/*diagnostic imaging
MH  - Diagnosis, Differential
MH  - Echocardiography/*methods
MH  - Endomyocardial Fibrosis/*diagnostic imaging/physiopathology
MH  - Female
MH  - Humans
MH  - Ischemia/diagnosis/diagnostic imaging
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Radiography
MH  - Ventricular Dysfunction/diagnosis/*diagnostic imaging
EDAT- 2010/07/14 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - ECHO1242 [pii]
AID - 10.1111/j.1540-8175.2010.01242.x [doi]
PST - ppublish
SO  - Echocardiography. 2011 Jan;28(1):62-8. doi: 10.1111/j.1540-8175.2010.01242.x.