PMID- 20620602
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20120605
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 200
IP  - 2
DP  - 2010 Jul 15
TI  - Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the 
      immunophenotype of chronic lymphocytic leukemia.
PG  - 170-4
LID - 10.1016/j.cancergencyto.2010.03.009 [doi]
AB  - Reciprocal IGH/14q32 translocations are detectable in 55-70% of patients with 
      plasma cell myeloma; e.g., the adverse t(4;14)(p16;q32) fusing the IGH and FGFR3 
      genes (immunoglobulin heavy chain/fibroblast growth factor receptor 3). In a 
      minority of patients with B-lineage chronic lymphocytic leukemia (CLL), 
      reciprocal IGH/14q32 translocations have been reported as well. We describe the 
      occurrence of a t(4;14)(p16;q32) in two lymphoma patients showing the 
      immunophenotype of B-CLL, which, to our knowledge, is the first report on such an 
      association. The first patient, a 72-year-old female, showed mature lymphocyte 
      infiltration of the bone marrow and marked splenomegaly. Immunophenotyping 
      revealed aberrant CD5 expression and light-chain lambda restriction on mature 
      B-lymphocytes corresponding to a B-CLL. Interphase fluorescence in situ 
      hybridization (FISH) plus chromosome banding revealed a t(4;14)(p16;q32) in 
      addition to an unbalanced der(16)t(8;16)(q23;p13) and a del(8)(p11). The second 
      patient, a male of 65 years, showed marked peripheral leukocytosis. 
      Immunophenotyping revealed the phenotype of CLL/PLL (chronic lymphocytic 
      leukemia/prolymphocytic leukemia). Again, FISH together with karyotyping revealed 
      a t(4;14)(p16;q32). These two cases with an t(4;14), but the immunophenotype of 
      B-CLL, demonstrate the genetic variability of B-cell lymphomas and the potential 
      of specific metaphase cultivation techniques using oligonucleotides to increase 
      our insights in the genetic pathways of these heterogeneous disorders.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Bacher, Ulrike
AU  - Bacher U
AD  - Interdisciplinary Clinic for Stem Cell Transplantation, University Cancer Center 
      Hamburg, Martinistrasse 52, Hamburg, Germany.
FAU - Haferlach, Torsten
AU  - Haferlach T
FAU - Schnittger, Susanne
AU  - Schnittger S
FAU - Weiss, Tamara
AU  - Weiss T
FAU - Burkhard, Oswald
AU  - Burkhard O
FAU - Bechtel, Britta
AU  - Bechtel B
FAU - Kern, Wolfgang
AU  - Kern W
FAU - Haferlach, Claudia
AU  - Haferlach C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - EC 2.7.10.1 (FGFR3 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 3)
SB  - IM
MH  - Aged
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 4
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Immunophenotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Lymphoma, B-Cell/*genetics
MH  - Male
MH  - Receptor, Fibroblast Growth Factor, Type 3/genetics
MH  - *Translocation, Genetic
EDAT- 2010/07/14 06:00
MHDA- 2010/07/31 06:00
CRDT- 2010/07/13 06:00
PHST- 2009/10/20 00:00 [received]
PHST- 2010/03/15 00:00 [revised]
PHST- 2010/03/30 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - S0165-4608(10)00142-1 [pii]
AID - 10.1016/j.cancergencyto.2010.03.009 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2010 Jul 15;200(2):170-4. doi: 
      10.1016/j.cancergencyto.2010.03.009.