PMID- 20623776
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20110329
IS  - 1099-1166 (Electronic)
IS  - 0885-6230 (Linking)
VI  - 26
IP  - 5
DP  - 2011 May
TI  - Neuropsychological profiles and short-term outcome in late-onset depression.
PG  - 458-65
LID - 10.1002/gps.2548 [doi]
AB  - OBJECTIVE: Neuropsychological impairments are common in older persons with 
      late-onset depression. This study examined the relationship between 
      neuropsychological profiles and short-term outcome in late-onset depression. 
      METHODS: A total of 54 non-demented Chinese elders presented with their first 
      major depressive episode after 60 years of age participated in this study and 
      were treated according to a standardised protocol. At entry, they were assessed 
      on neurological signs (Parkinsonian features and neurological soft signs) and 
      neuropsychological measures (executive function, psychomotor-speed, attention and 
      working memory, episodic memory, conceptualisation, construction and global 
      cognitive function). The Hamilton Depression Rating Scale (HAM-D) was 
      administered at baseline, the sixth and 12th week of treatment. RESULTS: Abnormal 
      fist-edge-palm (FEP) test, a sign reflecting impairment in motor sequencing, was 
      more common in non-remitters (defined as HAM-D score above 7) at the 12th week of 
      treatment. CONCLUSIONS: The FEP test may be included in the clinical assessment 
      for patients with late-onset depression to identify a susceptible group who may 
      require more intensive treatment. Further research is warranted to ascertain the 
      link between late-onset depression, neuropsychological deficits and prognosis.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Chui, William W H
AU  - Chui WW
AD  - Castle Peak Hospital, Hong Kong SAR, Hong Kong. cwh687@ha.org.hk
FAU - Cheung, Eric F C
AU  - Cheung EF
FAU - Lam, Linda C W
AU  - Lam LC
LA  - eng
PT  - Journal Article
DEP - 20100709
PL  - England
TA  - Int J Geriatr Psychiatry
JT  - International journal of geriatric psychiatry
JID - 8710629
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Attention/physiology
MH  - Cognition/physiology
MH  - Depressive Disorder/*physiopathology/psychology
MH  - Executive Function/physiology
MH  - Female
MH  - Hong Kong
MH  - Humans
MH  - Male
MH  - Memory/physiology
MH  - Parkinson Disease/physiopathology
MH  - Psychiatric Status Rating Scales
MH  - Psychomotor Performance/physiology
MH  - Severity of Illness Index
EDAT- 2010/07/14 06:00
MHDA- 2013/09/14 06:00
CRDT- 2010/07/13 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - 10.1002/gps.2548 [doi]
PST - ppublish
SO  - Int J Geriatr Psychiatry. 2011 May;26(5):458-65. doi: 10.1002/gps.2548. Epub 2010 
      Jul 9.