PMID- 20624085
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20161018
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 24
IP  - 7
DP  - 2010 Jul
TI  - Hydroflotation magnetic-aided endolumenal navigation-preliminary platform in
      ex-vivo setting for the next paradigm in minimally invasive urologic surgery.
PG  - 1161-4
LID - 10.1089/end.2010.0134 [doi]
AB  - BACKGROUND AND PURPOSE: Navigation of endolumenal devices, such as image
      rendering capsules, have been described for diagnostic purposes in the animal,
      and more recently, human models. In urology, the ureter is a prime lumenal
      structure that often needs to be explored for diagnostic and therapeutic
      purposes. A novel device using a flotation mechanism in a water-filled
      environment was developed and its navigation achieved with magnetic-aided
      guidance. The device was tested for propulsion and real-time control in the
      ex-vivo setting. MATERIALS AND METHODS: An endolumenal bionic worm (EBW) with a
      magnetic core was developed and introduced into synthetic lumens (SL) and
      supermarket chicken lumenal structures. The latter involved the gastrointestinal 
      lumenal tissue of supermarket chickens; ie, the ex-vivo equivalent of a ureteral 
      substitute lumen (USL). Navigation was graded by achievement of the EBW in
      propulsion to premarked sites, ability to remain static when necessary, and
      trauma to the USL. The structures were observed under the microscope for breech
      after the exercises. Navigation was observed in 10 SLs and 10 USLs. RESULTS: The 
      EBW was successfully steered using the magnetic guidance system with
      hydroflotation. Observation of endolumenal surfaces did not reveal evidence of
      trauma in either model. CONCLUSION: Hydroflotation magnetic-aided endolumenal
      navigation (HMAEN) of a microdevice was achieved endolumenally with targeted
      real-time control and with no observed trauma to the structures. HMAEN could
      potentially be used to guide devices like the EBW to permit diagnostic and
      therapeutic ureteroscopy including biopsy of ureteral and renal pelvis lesions,
      thus ushering in the platform for the next paradigm in endolumenal urologic
      procedures.
FAU - Kommu, Sashi S
AU  - Kommu SS
AD  - Section of Laparoscopic Urological Surgery, Department of Urology, The University
      Hospital, North Staffordshire NHS Trust, Stoke-on-Trent, United Kingdom.
      sashurol@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - Chickens
MH  - Electromagnetic Phenomena
MH  - Minimally Invasive Surgical Procedures/*methods
MH  - Models, Biological
MH  - Urologic Surgical Procedures/*methods
MH  - Water
EDAT- 2010/07/14 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/07/14 06:00
PHST- 2010/07/14 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - 10.1089/end.2010.0134 [doi]
PST - ppublish
SO  - J Endourol. 2010 Jul;24(7):1161-4. doi: 10.1089/end.2010.0134.