PMID- 20624697
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20161125
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 152
IP  - 3
DP  - 2010 Sep
TI  - Comparative endocrine disruptive effects of contaminants in ringed seals (Phoca 
      hispida) from Svalbard and the Baltic Sea.
PG  - 306-12
LID - 10.1016/j.cbpc.2010.05.006 [doi]
AB  - We investigated variables related to thyroid, vitamin A and calcitriol 
      homeostasis, immune function and tumour development in ringed seals (Phoca 
      hispida) from the polluted Baltic Sea and a less polluted reference location at 
      Svalbard, Norway. We also examined the relationships between the biological 
      variables and the concentrations of persistent organic pollutants (POPs) and 
      their hydroxylated (OH) metabolites. Our data show higher plasma concentrations 
      of free triiodothyronine (T3), and ratios of free and total T3 in Baltic seals as 
      compared to Svalbard seals. Baltic seals had also higher hepatic mRNA expressions 
      of deiodinase-I, thyroid hormone receptor beta, retinoic acid receptor alpha, 
      growth hormone receptor and interleukin-1beta compared to Svalbard seals. Levels 
      of plasma retinol were lower in the Baltic seals as compared to Svalbard seals. 
      No geographical difference was observed for other thyroid hormone levels and 
      hepatic retinoid levels. Ratios of free and total T3 were positively correlated 
      to OH-POPs in plasma. The results of the present study suggest that endocrine 
      homeostasis may be affected by contaminant and metabolite exposure in the Baltic 
      ringed seals with respect to circulating hormones and retinol and hepatic mRNA 
      expressions. In addition, OH-POPs may putatively produce the disruption of 
      thyroid hormone transport in plasma.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Routti, Heli
AU  - Routti H
AD  - Norwegian Polar Institute, Polar Environmental Centre, 9296 Tromso, Norway. 
      heli.routti@npolar.no
FAU - Arukwe, Augustine
AU  - Arukwe A
FAU - Jenssen, Bjorn Munro
AU  - Jenssen BM
FAU - Letcher, Robert J
AU  - Letcher RJ
FAU - Nyman, Madeleine
AU  - Nyman M
FAU - Backman, Christina
AU  - Backman C
FAU - Gabrielsen, Geir Wing
AU  - Gabrielsen GW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100601
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Biomarkers)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Interleukin-1beta)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Somatotropin)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (Thyroid Hormone Receptors beta)
RN  - 0 (Water Pollutants, Chemical)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 11103-57-4 (Vitamin A)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood/metabolism
MH  - Endocrine Disruptors/*metabolism
MH  - Female
MH  - Interleukin-1beta/blood/genetics/metabolism
MH  - Iodide Peroxidase/blood
MH  - Liver/enzymology/metabolism
MH  - Male
MH  - Phoca/blood/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptors, Retinoic Acid/blood/genetics/metabolism
MH  - Receptors, Somatotropin/blood/genetics
MH  - Retinoic Acid Receptor alpha
MH  - Thyroid Hormone Receptors beta/blood/genetics
MH  - Triiodothyronine/blood
MH  - Vitamin A/blood/genetics/metabolism
MH  - Water Pollutants, Chemical/*metabolism
EDAT- 2010/07/14 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/07/14 06:00
PHST- 2010/02/19 00:00 [received]
PHST- 2010/05/18 00:00 [revised]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/07/14 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - S1532-0456(10)00095-5 [pii]
AID - 10.1016/j.cbpc.2010.05.006 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2010 Sep;152(3):306-12. doi: 
      10.1016/j.cbpc.2010.05.006. Epub 2010 Jun 1.