PMID- 20624841
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211203
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Mar
TI  - Neocortical layer formation of human developing brains and lissencephalies: 
      consideration of layer-specific marker expression.
PG  - 588-96
LID - 10.1093/cercor/bhq125 [doi]
AB  - To investigate layer-specific molecule expression in human developing 
      neocortices, we performed immunohistochemistry of the layer-specific markers 
      (TBR1, FOXP1, SATB2, OTX1, CUTL1, and CTIP2), using frontal neocortices of the 
      dorsolateral precentral gyri of 16 normal controls, aged 19 gestational weeks to 
      1 year old, lissencephalies of 3 Miller-Dieker syndrome (MDS) cases, 2 X-linked 
      lissencephaly with abnormal genitalia (XLAG) cases, and 4 Fukuyama-type 
      congenital muscular dystrophy (FCMD) cases. In the fetal period, we observed 
      SATB2+ cells in layers II-IV, CUTL1+ cells in layers II-V, FOXP1+ cells in layer 
      V, OTX1+ cells in layers II or V, and CTIP2+ and TBR1+ cells in layers V and VI. 
      SATB2+ and CUTL1+ cells appeared until 3 months of age, but the other markers 
      disappeared after birth. Neocortices of MDS and XLAG infants revealed SATB2+, 
      CUTL1+, FOXP1+, and TBR1+ cells diffusely located in the upper layers. In fetal 
      FCMD neocortex, neurons labeled with the layer-specific markers located over the 
      glia limitans. The present study provided new knowledge indicating that the 
      expression pattern of these markers in the developing human neocortex was similar 
      to those in mice. Various lissencephalies revealed abnormal layer formation by 
      random migration.
FAU - Saito, Takashi
AU  - Saito T
AD  - Department of Mental Retardation and Birth Defect Research, National Center of 
      Neurology and Psychiatry, Kodaira, 187-8502, Japan.
FAU - Hanai, Sae
AU  - Hanai S
FAU - Takashima, Sachio
AU  - Takashima S
FAU - Nakagawa, Eiji
AU  - Nakagawa E
FAU - Okazaki, Shin
AU  - Okazaki S
FAU - Inoue, Takeshi
AU  - Inoue T
FAU - Miyata, Rie
AU  - Miyata R
FAU - Hoshino, Kyoko
AU  - Hoshino K
FAU - Akashi, Takumi
AU  - Akashi T
FAU - Sasaki, Masayuki
AU  - Sasaki M
FAU - Goto, Yu-ichi
AU  - Goto Y
FAU - Hayashi, Masaharu
AU  - Hayashi M
FAU - Itoh, Masayuki
AU  - Itoh M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100712
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Biomarkers)
RN  - 0 (Dcx protein, mouse)
RN  - 0 (Doublecortin Protein)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Doublecortin Protein
MH  - Fetus
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Infant, Newborn
MH  - Lissencephaly/metabolism/*pathology
MH  - Neocortex/*cytology/growth & development/metabolism
EDAT- 2010/07/14 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/07/14 06:00
PHST- 2010/07/14 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - bhq125 [pii]
AID - 10.1093/cercor/bhq125 [doi]
PST - ppublish
SO  - Cereb Cortex. 2011 Mar;21(3):588-96. doi: 10.1093/cercor/bhq125. Epub 2010 Jul 
      12.