PMID- 20625466 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211020 IS - 1095-7863 (Print) IS - 1095-7863 (Linking) VI - 2009 DP - 2009 Nov 1 TI - Design of a Real Time FPGA-based Three Dimensional Positioning Algorithm. PG - 1082-3654 AB - We report on the implementation and hardware platform of a real time Statistics-Based Processing (SBP) method with depth of interaction processing for continuous miniature crystal element (cMiCE) detectors using a sensor on the entrance surface design. Our group previously reported on a Field Programmable Gate Array (FPGA) SBP implementation that provided a two dimensional (2D) solution of the detector's intrinsic spatial resolution. This new implementation extends that work to take advantage of three dimensional (3D) look up tables to provide a 3D positioning solution that improves intrinsic spatial resolution. Resolution is most improved along the edges of the crystal, an area where the 2D algorithm's performance suffers. The algorithm allows an intrinsic spatial resolution of ~0.90 mm FWHM in X and Y and a resolution of ~1.90 mm FWHM in Z (i.e., the depth of the crystal) based upon DETECT2000 simulation results that include the effects of Compton scatter in the crystal. A pipelined FPGA implementation is able to process events in excess of 220k events per second, which is greater than the maximum expected coincidence rate for an individual detector. In contrast to all detectors being processed at a centralized host, as in the current system, a separate FPGA is available at each detector, thus dividing the computational load. A prototype design has been implemented and tested using a reduced word size due to memory limitations of our commercial prototyping board. FAU - Johnson-Williams, Nathan G AU - Johnson-Williams NG AD - The University of Washington Department of Electrical Engineering, Seattle, WA USA. FAU - Miyaoka, Robert S AU - Miyaoka RS FAU - Li, Xiaoli AU - Li X FAU - Lewellen, Tom K AU - Lewellen TK FAU - Hauck, Scott AU - Hauck S LA - eng GR - R01 CA136569/CA/NCI NIH HHS/United States GR - R33 EB001563/EB/NIBIB NIH HHS/United States GR - R01 EB002117-09/EB/NIBIB NIH HHS/United States GR - R33 EB001563-03/EB/NIBIB NIH HHS/United States GR - R01 CA136569-03/CA/NCI NIH HHS/United States GR - R21 EB001563/EB/NIBIB NIH HHS/United States GR - R33 EB001563-04/EB/NIBIB NIH HHS/United States GR - R01 EB002117/EB/NIBIB NIH HHS/United States GR - R01 EB002117-11/EB/NIBIB NIH HHS/United States PT - Journal Article PL - United States TA - IEEE Nucl Sci Symp Conf Rec (1997) JT - IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium JID - 101492453 PMC - PMC2898207 MID - NIHMS207137 EDAT- 2010/07/14 06:00 MHDA- 2010/07/14 06:01 PMCR- 2010/11/01 CRDT- 2010/07/14 06:00 PHST- 2010/07/14 06:00 [entrez] PHST- 2010/07/14 06:00 [pubmed] PHST- 2010/07/14 06:01 [medline] PHST- 2010/11/01 00:00 [pmc-release] AID - 10.1109/NSSMIC.2009.5401848 [doi] PST - ppublish SO - IEEE Nucl Sci Symp Conf Rec (1997). 2009 Nov 1;2009:1082-3654. doi: 10.1109/NSSMIC.2009.5401848.