PMID- 20626168
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20100714
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Apr
TI  - [Advances in rapid prenatal detection of fetal chromosome abnormalities].
PG  - 359-63
AB  - Rapid prenatal detection methods, including molecular cytogenetic analysis and 
      ultrasonographic markers, are very important for prenatal diagnosis. The use of 
      molecular cytogenetic techniques has significantly improved the rapid detection 
      of aneuploidy and identification of small structural abnormalities of fetal 
      chromosomes. At present, commonly used molecular cytogenetic techniques include 
      fluorescence in situ hybridization (FISH), quantitative fluorescence PCR 
      (QF-PCR), multiplex ligation-dependent probe amplification (MLPA) and 
      microarray-based comparative genomic hybridization (array CGH). There is 
      extensive evidence that major chromosomal abnormalities can be effectively 
      detected by ultrasonography in the first and second trimesters of pregnancy. So 
      we can combine molecular cytogenetic techniques with ultrasonographic markers to 
      improve the identification of aneuploidies for chromosomes and the accuracy of 
      prenatal diagnosis, and to reduce birth defects in newborns.
FAU - Wang, Jie
AU  - Wang J
AD  - PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital 
      of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
FAU - Cui, Ying-Xia
AU  - Cui YX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Disorders/*diagnosis
MH  - Cytogenetic Analysis
MH  - Electron Probe Microanalysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Nucleic Acid Hybridization
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
MH  - Protein Array Analysis
MH  - Ultrasonography, Prenatal
RF  - 31
EDAT- 2010/07/16 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2010 Apr;16(4):359-63.