PMID- 20626294
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20221207
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 30
IP  - 7
DP  - 2010 Jul
TI  - Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of 
      obesity in Japanese, white, and Japanese American middle-aged men.
PG  - 541-8
LID - 10.1089/jir.2009.0114 [doi]
AB  - This study examines the differences in circulating levels of cytokines among 
      Japanese in Japan (JJ), Japanese Americans (JA), and whites and their 
      associations with obesity and marine n-3 fatty acids (FA) in a cross-sectional 
      population-based study of 297 men aged 40-49 (100 JJ, 99 whites, and 98 JA). 
      Experimental studies show that cytokines are associated with obesity positively 
      and marine n-3 FA inversely. Serum interleukin-1alpha (IL-1alpha), IL-1 receptor 
      agonist (IL-1ra), IL-4, IL-8, IL-10, inducible protein-10 (IP-10), tumor necrosis 
      factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and marine 
      n-3 FA were determined. Body mass index (BMI), waist circumference, and computed 
      tomography-measured visceral and subcutaneous adipose tissues were determined. 
      The JJ had significantly lower levels of IL-1alpha, IL-4, IL-8, MCP-1, and 
      TNF-alpha than whites and JA. Whites and JA had similar levels of IL-1alpha, 
      IL-4, and IL-8 whereas whites had significantly higher levels of MCP-1 and 
      TNF-alpha than JA. The JJ were least obese (BMI (kg/m(2)), mean +/- standard 
      deviation) 23.6 +/- 2.8, 27.9 +/- 4.6, and 27.9 +/- 4.5 for JJ, whites, and JA, 
      respectively. The JJ had marine n-3 FA about 100% higher than whites and JA 
      (serum marine n-3 FA (%), median (interquartile range) 8.79 (7.41, 11.16), 3.47 
      (2.63, 4.83), and 4.44 (3.33, 6.01) for JJ, whites, and JA, respectively). 
      Generally cytokines had weak and nonsignificant associations with indices of 
      obesity and nonsignificant associations with marine n-3 FA. BMI had significant 
      inverse associations with IL-1alpha, IL-4, and IL-8 in JA (P < 0.05). Marine n-3 
      FA had marginally significant inverse associations with IL-8 in JJ (P = 0.055) 
      and TNF-alpha in whites (P = 0.076). The JJ had lower levels of many cytokines 
      than whites and JA. Generally cytokines had weak and nonsignificant associations 
      with indices of obesity and marine n-3 FA. Further investigation is needed to 
      determine why JJ had lower circulating levels of cytokines.
FAU - Sekikawa, Akira
AU  - Sekikawa A
AD  - Department of Epidemiology, Graduate School of Public Health, University of 
      Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. akira@pitt.edu
FAU - Kadowaki, Takashi
AU  - Kadowaki T
FAU - Curb, J David
AU  - Curb JD
FAU - Evans, Rhobert W
AU  - Evans RW
FAU - Maegawa, Hiroshi
AU  - Maegawa H
FAU - Abbott, Robert D
AU  - Abbott RD
FAU - Sutton-Tyrrell, Kim
AU  - Sutton-Tyrrell K
FAU - Okamura, Tomonori
AU  - Okamura T
FAU - Shin, Chol
AU  - Shin C
FAU - Edmundowicz, Daniel
AU  - Edmundowicz D
FAU - Kadota, Aya
AU  - Kadota A
FAU - Choo, Jina
AU  - Choo J
FAU - El-Saed, Aiman
AU  - El-Saed A
FAU - Ueshima, Hirotsugu
AU  - Ueshima H
FAU - Kuller, Lewis H
AU  - Kuller LH
CN  - ERA JUMP Study group
LA  - eng
GR  - R01 HL068200/HL/NHLBI NIH HHS/United States
GR  - HL071561/HL/NHLBI NIH HHS/United States
GR  - R01 HL68200/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Cytokines)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
EIN - J Interferon Cytokine Res. 2012 Jan;32(1):52
MH  - Adipose Tissue/pathology
MH  - Adult
MH  - *Asian
MH  - *Asian People
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Cytokines/blood
MH  - Fatty Acids, Omega-3/blood
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/*immunology/pathology/physiopathology
MH  - United States
MH  - *White People
PMC - PMC2950061
EDAT- 2010/07/16 06:00
MHDA- 2011/02/05 06:00
PMCR- 2011/07/01
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.1089/jir.2009.0114 [pii]
AID - 10.1089/jir.2009.0114 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2010 Jul;30(7):541-8. doi: 10.1089/jir.2009.0114.