PMID- 20626311
OWN - NLM
STAT- MEDLINE
DCOM- 20101001
LR  - 20131121
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 47
IP  - 7
DP  - 2010 Sep
TI  - Determinants of exhaled nitric oxide levels (FeNO) in childhood atopic asthma: 
      evidence for neonatal respiratory distress as a factor associated with low FeNO 
      levels.
PG  - 810-6
LID - 10.3109/02770903.2010.489245 [doi]
AB  - BACKGROUND: In allergic asthmatic children exhaled nitric oxide (FeNO) levels are 
      related to eosinophilic inflammation by correlation analysis. Whether FeNO can be 
      modified by factors potentially influencing the natural history of asthma in 
      early life is not known. OBJECTIVE: To evaluate the frequency of anamnestic 
      factors influencing the natural history of asthma and to identify potential 
      determinants for elevated or low FeNO levels by multivariate analysis. METHODS: 
      One hundred seventy-one children with mild-moderate asthma were stratified 
      according to their FeNO levels into three groups: low (<20 ppb), mid (20-40 ppb), 
      and high (>40 ppb). The frequency of nine anamnestic factors together with 
      indices of allergic sensitization (total and allergen-specific immunoglobulin E 
      [IgE], blood eosinophil counts) and of airflow limitation (forced expiratory 
      volume in one second [FEV(1)]% predicted) were evaluated. Results. Among factors 
      related to the patient history, neonatal respiratory distress was reported only 
      in children with low FeNO levels, whereas this factor was never reported in 
      children with mid-to-high FeNO levels (p = .008). As compared with low FeNO 
      group, mid and high FeNO groups showed higher eosinophil counts and a tendency to 
      have lower FEV(1) values. By multivariate analysis, four factors (eosinophils 
      >300 cells/mm(3), cat-specific IgE, house dust mites [HDM]-specific IgE, FEV(1) </= 
      86% predicted) turned out to be significantly associated with mid-high FeNO 
      levels and two factors (eosinophils >600 cells/mm(3), total IgE >355 kU/L) with 
      high FeNO levels. CONCLUSIONS: Besides confirming the well-known tight 
      association between blood eosinophilia and/or allergic sensitization and FeNO, 
      these data provide new evidence for neonatal respiratory distress as potential 
      factor associated with low FeNO levels in childhood atopic asthma.
FAU - Ricciardolo, Fabio L M
AU  - Ricciardolo FL
AD  - Pulmonary and Allergy Disease Paediatric Unit, G. Gaslini Institute, Genoa, 
      Italy. fabioluigimassimo.ricciardolo@unito.it
FAU - Silvestri, Michela
AU  - Silvestri M
FAU - Pistorio, Angela
AU  - Pistorio A
FAU - Strozzi, Mariachiara M
AU  - Strozzi MM
FAU - Tosca, Maria A
AU  - Tosca MA
FAU - Bellodi, Simona C
AU  - Bellodi SC
FAU - Battistini, Elena
AU  - Battistini E
FAU - Gardella, Chiara
AU  - Gardella C
FAU - Rossi, Giovanni A
AU  - Rossi GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Asthma/*diagnosis/metabolism
MH  - *Breath Tests
MH  - Child
MH  - Exhalation
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Nitric Oxide/*analysis
MH  - Pyroglyphidae/immunology
MH  - Respiratory Distress Syndrome, Newborn/*metabolism
EDAT- 2010/07/16 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 10.3109/02770903.2010.489245 [doi]
PST - ppublish
SO  - J Asthma. 2010 Sep;47(7):810-6. doi: 10.3109/02770903.2010.489245.