PMID- 20627038
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 49
IP  - 4
DP  - 2010 Apr
TI  - [The association study of serum total bilirubin, plasma N-terminal proBNP and 
      invasive hemodynamic parameters in patients with heart failure].
PG  - 313-5
AB  - OBJECTIVE: To explore the correlation among serum total bilirubin (TBil), 
      invasive hemodynamic parameters, plasma N-terminal proBNP (NT-proBNP) and C 
      reactive protein (CRP) in patients with heart failure. METHODS: Invasive 
      hemodynamic parameters derived from Swan-Ganz catheter, TBil, plasma NT-proBNP 
      and CRP within 12 hours after hospital admission were analyzed in 130 patients 
      with chronic heart failure [New York Heart Association (NYHA) class II-IV]. 
      RESULTS: Compared with those in non-hyperbilirubinemia group, pulmonary capillary 
      wedge pressure (PCWP), NT-proBNP and left ventriculus ejection fraction were 
      different significantly in total hyperbilirubinemia group [(26.09 vs 16.00) mm Hg 
      (1 mm Hg = 0.133 kPa), (3.36 vs 2.91) pmol/L, (34.12 vs 28.92)%, P < 0.05]. The 
      serum TBil increased significantly in higher PCWP, right atrial pressure and 
      NT-proBNP groups than those in lower level groups [(32.22 vs 24.17), (37.52 vs 
      24.19), (32.14 vs 16.74) pmol/L, P < 0.05]. Partial correlation analysis showed 
      serum TBil was associated with PCWP, right atrial pressure, pulmonary vascular 
      resistance index and NT-proBNP respectively (r = 0.21, P = 0.02; r = 0.33, P < 
      0.01; r = 0.20, P = 0.04; r = 0.37, P < 0.01, respectively). Multiple linear 
      regression analysis showed both right atrial pressure and NT-proBNP correlated 
      independently with serum TBil (beta = 0.39, P < 0.01; beta = 0.29, P = 0.01, 
      respectively). CONCLUSION: For patients with heart failure, serum TBil correlated 
      well with right atrial pressure, PCWP and NT-proBNP; it is a reliable indicator 
      for exact clinical evaluation of heart failure.
FAU - Zhang, Yu-hui
AU  - Zhang YH
AD  - Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, 
      China.
FAU - Zhang, Jian
AU  - Zhang J
FAU - Wang, Dong
AU  - Wang D
FAU - Lu, Rong
AU  - Lu R
FAU - Wei, Bing-qi
AU  - Wei BQ
FAU - Kang, Lian-ming
AU  - Kang LM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bilirubin/*blood
MH  - Female
MH  - Heart Failure/*blood/*physiopathology
MH  - *Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Young Adult
EDAT- 2010/07/16 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2010 Apr;49(4):313-5.