PMID- 20627626
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20171116
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 29
IP  - 9
DP  - 2010 Sep
TI  - Transfusion-related acute lung injury (TRALI) in graft by blood donor antibodies 
      against host leukocytes.
PG  - 1067-70
LID - 10.1016/j.healun.2010.04.019 [doi]
AB  - It is unknown the extent to which transfusion-related acute lung injury (TRALI) 
      contributes to primary graft dysfunction (PGD), the leading cause of death after 
      lung transplantation. In this case of suspected transfusion-associated acute 
      bilateral graft injury in a 61-year-old idiopathic pulmonary fibrosis patient, 
      recipient sera from before and after transplantation/transfusion, as well as the 
      sera of 22 of the 24 implicated blood donors, were individually screened by 
      Luminex bead assay for the presence of human leukocyte antigen (HLA) antibodies, 
      with recipient and lung donor HLA typing to explore for cognate relationships. A 
      red-cell-unit donor-source anti-Cw6 antibody, cognate with the HLA type of the 
      recipient, was identified. This is the second reported case of TRALI in the 
      setting of lung transplantation, and the first to show an associated interaction 
      between donor antibodies (in a low-plasma volume product) with recipient 
      leukocytes (rather than graft antigens); therefore, it should be considered in 
      the differential diagnosis of PGD.
CI  - Copyright 2010 International Society for Heart and Lung Transplantation. 
      Published by Elsevier Inc. All rights reserved.
FAU - Goodwin, Jodi
AU  - Goodwin J
AD  - Department of Respirology, McMaster University, Hamilton, Ontario, Canada.
FAU - Tinckam, Kathryn
AU  - Tinckam K
FAU - denHollander, Neal
AU  - denHollander N
FAU - Haroon, Ayesha
AU  - Haroon A
FAU - Keshavjee, Shaf
AU  - Keshavjee S
FAU - Cserti-Gazdewich, Christine M
AU  - Cserti-Gazdewich CM
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100608
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (HLA-D Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Aspergillosis/complications
MH  - *Blood Donors
MH  - Blood Grouping and Crossmatching
MH  - Fatal Outcome
MH  - HLA-D Antigens/immunology
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Hypertension, Pulmonary/surgery
MH  - Isoantibodies/*adverse effects/immunology
MH  - Leukocytes/immunology
MH  - Lung Transplantation/*immunology/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Organ Failure
MH  - Pulmonary Fibrosis/surgery
MH  - Radiography, Thoracic
MH  - *Transfusion Reaction
EDAT- 2010/07/16 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/03/15 00:00 [received]
PHST- 2010/04/13 00:00 [revised]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - S1053-2498(10)00276-7 [pii]
AID - 10.1016/j.healun.2010.04.019 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2010 Sep;29(9):1067-70. doi: 
      10.1016/j.healun.2010.04.019. Epub 2010 Jun 8.