PMID- 20628884
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211020
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 110
IP  - 5
DP  - 2010 Nov
TI  - High-intensity exercise and carbohydrate-reduced energy-restricted diet in obese 
      individuals.
PG  - 893-903
LID - 10.1007/s00421-010-1571-y [doi]
AB  - Continuous high glycemic load and inactivity challenge glucose homeostasis and 
      fat oxidation. Hyperglycemia and high intramuscular glucose levels mediate 
      insulin resistance, a precursor state of type 2 diabetes. The aim was to 
      investigate whether a carbohydrate (CHO)-reduced diet combined with 
      high-intensity interval training (HIIT) enhances the beneficial effects of the 
      diet alone on insulin sensitivity and fat oxidation in obese individuals. 
      Nineteen obese subjects underwent 14 days of CHO-reduced and energy-restricted 
      diet. Ten of them combined the diet with HIIT (4 min bouts at 90% VO(2peak) up to 
      10 times, 3 times a week). Oral glucose insulin sensitivity (OGIS) increased 
      significantly in both groups; [diet-exercise (DE) group: pre 377 +/- 70, post 
      396 +/- 68 mL min(-1) m(-2); diet (D) group: pre 365 +/- 91, post 
      404 +/- 87 mL min(-1) m(-2); P < 0.001]. Fasting respiratory exchange ratio (RER) 
      decreased significantly in both groups (DE group: pre 0.91 +/- 0.06, post 
      0.88 +/- 0.06; D group: pre 0.92 +/- 0.07, post 0.86 +/- 0.07; P = 0.002). VO(2peak) 
      increased significantly in the DE group (pre 27 +/- 5, post 
      32 +/- 6 mL kg(-1) min(-1); P < 0.001), but not in the D group (pre 26 +/- 9, post 
      26 +/- 8 mL kg(-1) min(-1)). Lean mass and resistin were preserved only in the DE 
      group (P < 0.05). Fourteen days of CHO-reduced diet improved OGIS and fat 
      oxidation (RER) in obese subjects. The energy-balanced HIIT did not further 
      enhance these parameters, but increased aerobic capacity (VO(2peak)) and 
      preserved lean mass and resistin.
FAU - Sartor, Francesco
AU  - Sartor F
AD  - School of Sport, Health and Exercise Sciences, Bangor University, George 
      Building, Holyhead Road, Bangor, Gwynedd, UK.
FAU - de Morree, Helma M
AU  - de Morree HM
FAU - Matschke, Verena
AU  - Matschke V
FAU - Marcora, Samuele M
AU  - Marcora SM
FAU - Milousis, Athanasios
AU  - Milousis A
FAU - Thom, Jeanette M
AU  - Thom JM
FAU - Kubis, Hans-Peter
AU  - Kubis HP
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100714
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Resistin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism/physiology
MH  - *Caloric Restriction
MH  - *Diet, Carbohydrate-Restricted
MH  - Exercise/*physiology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood/metabolism/physiology
MH  - Insulin Resistance/physiology
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Leptin/blood/metabolism/physiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/*metabolism/*physiopathology
MH  - Oxygen Consumption/physiology
MH  - Resistin/blood/metabolism/physiology
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2010/07/16 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/06/30 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - 10.1007/s00421-010-1571-y [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2010 Nov;110(5):893-903. doi: 10.1007/s00421-010-1571-y. Epub 
      2010 Jul 14.