PMID- 2062900
OWN - NLM
STAT- MEDLINE
DCOM- 19910808
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 49
IP  - 2
DP  - 1991 Feb
TI  - Effect of glucoprivation on glutamate decarboxylase activity in the ventromedial 
      nucleus.
PG  - 295-9
AB  - Activity of the GABA-synthesizing enzyme, glutamate decarboxylase (GAD), was 
      measured in brain areas involved in glucoregulation 60 min after a glucoprivie 
      challenge. The rate of GAD activity in the ventromedial nucleus of the 
      hypothalamus (VMN) increased in a dose-dependent manner in response to 
      intraperitoneal injection of 2-deoxy-D-glucose (2-DG). The increase in VMN GAD 
      activity was significantly correlated with an increase in food intake (r2 = .77, 
      p less than 0.01). The increase in VMN GAD activity was not due to the higher 
      food intake since rats receiving 2-DG and denied access to food also had elevated 
      rates of VMN GAD activity. VMN GAD activity was increased 28% and 32% after 
      intracerebroventricular injection of 2-DG or 5-thioglucose, respectively. The 
      rates of GAD activity in the lateral hypothalamus and area postrema were not 
      affected by either peripherally or centrally administered 2-DG. The increase in 
      VMN GAD activity after glucoprivation may be involved in the regulation of blood 
      glucose by influencing food intake.
FAU - Beverly, J L
AU  - Beverly JL
AD  - Department of Physiological Sciences, School of Veterinary Medicine, University 
      of California, Davis, CA 95616.
FAU - Martin, R J
AU  - Martin RJ
LA  - eng
GR  - DK 07355/DK/NIDDK NIH HHS/United States
GR  - HD 22226/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Blood Glucose)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Brain Mapping
MH  - Eating/physiology
MH  - Energy Metabolism/physiology
MH  - Glutamate Decarboxylase/*physiology
MH  - Homeostasis/physiology
MH  - Hypothalamic Area, Lateral/*physiology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Ventromedial Hypothalamic Nucleus/*physiology
MH  - gamma-Aminobutyric Acid/*biosynthesis
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
AID - 0031-9384(91)90046-Q [pii]
AID - 10.1016/0031-9384(91)90046-q [doi]
PST - ppublish
SO  - Physiol Behav. 1991 Feb;49(2):295-9. doi: 10.1016/0031-9384(91)90046-q.