PMID- 20630802
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20100806
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 31
IP  - 8
DP  - 2010 Aug
TI  - Extending killer Ig-like receptor function: from HLA class I recognition to 
      sensors of microbial products.
PG  - 289-94
LID - 10.1016/j.it.2010.05.007 [doi]
AB  - Killer Ig-like receptors (KIRs) are human natural killer (NK) receptors that 
      recognize allotypic determinants of human leukocyte antigen (HLA) class I. 
      Inhibitory KIRs discriminate normal cells from tumour or virus-infected cells 
      that have lost or reduced HLA class I expression. Donor NK cell "alloeffector" 
      responses are exploited in haploidentical haematopoietic stem cell 
      transplantation to treat leukaemia. NK cells also express several toll-like 
      receptors (TLRs) that increase NK cell cytotoxicity and cytokine release in 
      response to ligands. Surprisingly, KIR3DL2 binds the TLR ligand 
      CpG-oligodexynucleotides, and together, they are co-internalized and translocated 
      to TLR9-rich early endosomes. This novel KIR-associated function offers clues to 
      understanding the NK cell response to microbial infection, and extends the role 
      played by KIRs in immune defence.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Sivori, Simona
AU  - Sivori S
AD  - Department of Experimental Medicine and Center of Excellence for Biomedical 
      Research, University of Genova, Italy.
FAU - Falco, Michela
AU  - Falco M
FAU - Moretta, Lorenzo
AU  - Moretta L
FAU - Moretta, Alessandro
AU  - Moretta A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100712
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - CpG Islands
MH  - Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Receptors, KIR/*immunology
EDAT- 2010/07/16 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/03/30 00:00 [received]
PHST- 2010/05/25 00:00 [revised]
PHST- 2010/05/28 00:00 [accepted]
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - S1471-4906(10)00076-1 [pii]
AID - 10.1016/j.it.2010.05.007 [doi]
PST - ppublish
SO  - Trends Immunol. 2010 Aug;31(8):289-94. doi: 10.1016/j.it.2010.05.007. Epub 2010 
      Jul 12.