PMID- 20631238
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20101202
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 51
IP  - 12
DP  - 2010 Dec
TI  - Relationship between visual field sensitivity and macular ganglion cell complex 
      thickness as measured by spectral-domain optical coherence tomography.
PG  - 6401-7
LID - 10.1167/iovs.09-5035 [doi]
AB  - PURPOSE: To evaluate the strength and pattern of the relationship between visual 
      field (VF) mean sensitivity (MS), assessed by standard automated perimetry (SAP), 
      and macular ganglion cell complex thickness (GCCT), measured with spectral-domain 
      optical coherence tomography (SD-OCT). METHODS: Ninety-seven glaucoma patients 
      were enrolled. GCCT, determined by ganglion cell complex (GCC) scanning, and two 
      peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements, using 
      the NHM4 (RNFL1) and RNFL 3.45 (RNFL2) modes, were recorded. MS was recorded on 
      the decibel (dB) and 1/L scales. The relationship between function (MS) and 
      structure (GCC, pRNFLT) was sought. RESULTS: The association of MS (in decibels) 
      with GCC global (r = 0.445) and sectoral (superior, r = 0.528; inferior, r = 
      0.370) thicknesses was not significantly different from that of MS to global 
      (RNFL1, r = 0.505; RNFL2, r = 0.498) and sectoral (RNFL 1 superior, r = 0.559; 
      inferior, r = 0.440; RNFL 2 superior, r = 0.535; inferior, r = 0.443) pRNFLT, on 
      linear regression analysis. The relationship pattern was curvilinear on the dB 
      scale against GCCT and RNFLT. Logarithmic regression of MS (using both the dB and 
      1/L scales) against GCCT and RNFLT was better than linear regression in 
      describing the pattern of association. CONCLUSIONS: GCCT, determined by SD-OCT, 
      showed correlation to MS of a strength similar to that demonstrated between MS 
      and pRNFLT.
FAU - Cho, Jung Woo
AU  - Cho JW
AD  - Department of Ophthalmology, University of Ulsan, College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Sung, Kyung Rim
AU  - Sung KR
FAU - Lee, Suhwan
AU  - Lee S
FAU - Yun, Sung-Cheol
AU  - Yun SC
FAU - Kang, Sung Yong
AU  - Kang SY
FAU - Choi, Jaewan
AU  - Choi J
FAU - Na, Jung Hwa
AU  - Na JH
FAU - Lee, Youngrok
AU  - Lee Y
FAU - Kook, Michael S
AU  - Kook MS
LA  - eng
PT  - Journal Article
DEP - 20100714
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Vision Disorders/*diagnosis
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
EDAT- 2010/07/16 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - iovs.09-5035 [pii]
AID - 10.1167/iovs.09-5035 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6401-7. doi: 10.1167/iovs.09-5035. 
      Epub 2010 Jul 14.