PMID- 20631443
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20190827
IS  - 1348-2246 (Electronic)
IS  - 0910-6340 (Linking)
VI  - 26
IP  - 7
DP  - 2010
TI  - Simultaneous voltammetric determination of enrofloxacin and ciprofloxacin in 
      urine and plasma using multiwall carbon nanotubes modified glassy carbon 
      electrode by least-squares support vector machines.
PG  - 803-8
AB  - A simple and sensitive method is proposed for the electrochemical determination 
      of enrofloxacin (ENRO) and its primary metabolite ciprofloxacin (CIPRO) at a 
      multiwall carbon nanotubes/glassy carbon electrode (MWCNT/GCE) using a 
      least-squares support vector machine (LS-SVM) and linear sweep voltammetry. 
      Simultaneous determination of ENRO and CIPRO at bare glassy carbon is associated 
      with certain difficulties due to voltammogram overlapping and their low 
      sensitivity. The resolution of the mixture was carried out using LS-SVM as a 
      multivariate calibration method. Under the optimum conditions at pH 7.0, the 
      linear sweep currents increased linearly with ENRO and CIPRO concentrations in 
      ranges of 2.0-780.0 micromol L(-1) (0.7-280.3 microg mL(-1)) and 3.0-1200 
      micromol L(-1) (1.0-397.7 microg mL(-1)), respectively. The detection limits for 
      ENRO and CIPRO were 0.5 and 0.9 micromol L(-1), respectively. The proposed method 
      was applied to simultaneously determine both compounds in human urine, plasma and 
      in pharmaceutical samples.
FAU - Ensafi, Ali A
AU  - Ensafi AA
AD  - Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, 
      Iran. Ensafi@cc.iut.ac.ir
FAU - Taei, M
AU  - Taei M
FAU - Khayamian, T
AU  - Khayamian T
FAU - Hasanpour, F
AU  - Hasanpour F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Anal Sci
JT  - Analytical sciences : the international journal of the Japan Society for 
      Analytical Chemistry
JID - 8511078
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Nanotubes, Carbon)
RN  - 3DX3XEK1BN (Enrofloxacin)
RN  - 5E8K9I0O4U (Ciprofloxacin)
SB  - IM
MH  - Anti-Bacterial Agents/*analysis/blood/urine
MH  - *Artificial Intelligence
MH  - Blood Chemical Analysis/instrumentation/*methods
MH  - Calibration
MH  - Ciprofloxacin/analysis/blood/urine
MH  - Electrochemistry/instrumentation/*methods
MH  - Electrodes
MH  - Enrofloxacin
MH  - Fluoroquinolones/analysis/blood/urine
MH  - Glass/*chemistry
MH  - Humans
MH  - Least-Squares Analysis
MH  - Multivariate Analysis
MH  - Nanotubes, Carbon/*chemistry
MH  - Time Factors
MH  - Urinalysis/instrumentation/*methods
EDAT- 2010/07/16 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - JST.JSTAGE/analsci/26.803 [pii]
AID - 10.2116/analsci.26.803 [doi]
PST - ppublish
SO  - Anal Sci. 2010;26(7):803-8. doi: 10.2116/analsci.26.803.