PMID- 20632452
OWN - NLM
STAT- MEDLINE
DCOM- 20101018
LR  - 20220331
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 16
IP  - 27
DP  - 2010 Jul 21
TI  - Impact of human leukocyte antigen mismatching on outcomes of liver 
      transplantation: a meta-analysis.
PG  - 3457-64
AB  - AIM: To assess the effect of human leukocyte antigen (HLA) mismatching on liver 
      graft outcome and acute rejection from a meta-analysis of available cohort 
      studies. METHODS: Articles in PubMed/MEDLINE, EMBASE and the Cochrane database 
      from January 1970 to June 2009, including non-English literature identified in 
      these databases, were searched. Only studies comparing HLA or sub-phenotype 
      matching with mismatching were extracted. The percentage of graft survival was 
      extracted by "Engauge Digitizer" from survival curves if the raw data were not 
      displayed. A meta-analysis was performed when at least 3 studies provided data. 
      RESULTS: Sixteen studies met the inclusion criteria. A lower number of HLA 
      mismatches (0-2 vs 3-6) did reduce the incidence of acute rejection (relative 
      risk: 0.77, P = 0.03). The degree of HLA mismatching (0-2 vs 3-6) had no 
      significant effect on 1-year [hazard ratio (HR): 1.04, P = 0.68] and 5-year (HR: 
      1.09, P = 0.38) graft survival. In sub-phenotype analysis, the degree of HLA-A, B 
      and DR mismatching (0 vs 1-2) had no significant effect on 1-year and 5-year 
      graft survival, either. The HRs and P-values were 0.95, 0.71 (HLA-A, 1-year); 
      1.06, 0.60 (HLA-A, 5-year); 0.77, 0.16 (HLA-B, 1-year); 1.07, 0.56 (HLA-DR, 
      1-year); 1.18, 0.23 (HLA-DR, 5-year), respectively. CONCLUSION: The results of 
      this systematic review imply that good HLA compatibility can reduce the incidence 
      of acute rejection in spite of having no influence on graft outcomes. To obtain a 
      short recovery time and minimize rejection post transplantation, HLA matching 
      studies should be considered before the operation.
FAU - Lan, Xiang
AU  - Lan X
AD  - Department of Hepatobiliary Surgery and Liver Transplantation Centre, Children's 
      Hospital of Chongqing Medical University, 136, Zhongshan 2nd Road, Yuzhong 
      District, Chongqing 400014, China.
FAU - Zhang, Ming-Man
AU  - Zhang MM
FAU - Pu, Cong-Lun
AU  - Pu CL
FAU - Guo, Chun-Bao
AU  - Guo CB
FAU - Kang, Quan
AU  - Kang Q
FAU - Li, Ying-Chun
AU  - Li YC
FAU - Dai, Xiao-Ke
AU  - Dai XK
FAU - Deng, Yu-Hua
AU  - Deng YH
FAU - Xiong, Qiang
AU  - Xiong Q
FAU - Ren, Zhi-Mei
AU  - Ren ZM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Databases, Factual
MH  - Epitopes
MH  - Graft Rejection/*immunology
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Liver Transplantation/adverse effects/immunology
MH  - Treatment Outcome
PMC - PMC2904896
EDAT- 2010/07/16 06:00
MHDA- 2010/10/19 06:00
PMCR- 2010/07/21
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/10/19 06:00 [medline]
PHST- 2010/07/21 00:00 [pmc-release]
AID - 10.3748/wjg.v16.i27.3457 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2010 Jul 21;16(27):3457-64. doi: 10.3748/wjg.v16.i27.3457.