PMID- 20633772
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20100716
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 201
IP  - 1
DP  - 2010 Aug
TI  - Amplification of IGH/CCND1 fusion gene in a primary plasma cell leukemia case.
PG  - 62-5
LID - 10.1016/j.cancergencyto.2010.05.006 [doi]
AB  - The IGH/CCND1 fusion gene has been reported in many hematologic tumors such as 
      mantle cell lymphoma, chronic lymphocytic leukemia, prolymphocytic leukemia, 
      multiple myeloma, and plasma cell leukemia. We report a case of plasma cell 
      leukemia showing five IGH/CCND1 fusion signals by interphase fluorescence in situ 
      hybridization (FISH). Conventional cytogenetic analysis and multicolor spectral 
      karyotyping showed a complex karyotype that did not include t(11;14). Metaphase 
      FISH studies revealed three IGH/CCND1 fusion signals, two of which were amplified 
      signals. These findings indicate that IGH/CCND1 fusion gene was amplified and 
      interspersed in several chromosomes. The patient was treated with intensive 
      chemotherapy. However, the clinical course was very aggressive. The amplification 
      of the IGH/CCND1 fusion gene may contribute to the aggressive course of the 
      disease. To our knowledge, this is the first case showing amplification of the 
      IGH/CCND1 gene in plasma cell neoplasms.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Ishigaki, Tomohiro
AU  - Ishigaki T
AD  - Department of Clinical Laboratory, Tokyo Medical and Dental University Hospital, 
      1-5-45 Yushima Bunkyo-ku, Tokyo, Japan. ishigaki.mlab@tmd.ac.jp
FAU - Sasaki, Kouji
AU  - Sasaki K
FAU - Watanabe, Ken
AU  - Watanabe K
FAU - Nakamura, Norihiko
AU  - Nakamura N
FAU - Toyota, Shigeo
AU  - Toyota S
FAU - Kobayashi, Hirofumi
AU  - Kobayashi H
FAU - Tohda, Shuji
AU  - Tohda S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (CCND1 protein, human)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Cyclin D1/*genetics
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Plasma Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Spectral Karyotyping
EDAT- 2010/07/17 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/01/07 00:00 [received]
PHST- 2010/05/06 00:00 [revised]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - S0165-4608(10)00199-8 [pii]
AID - 10.1016/j.cancergencyto.2010.05.006 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2010 Aug;201(1):62-5. doi: 
      10.1016/j.cancergencyto.2010.05.006.